Results 151 to 160 of about 385,028 (263)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Phage-assisted evolution of allosteric protein switches. [PDF]

Nat Commun
Southern NT, von Bachmann A, Hovsepyan A, Griebl M, Wolf B, Lemmen N, Kroell AS, Westermann S, Mathony J, Niopek D.   +9 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Genome association of carbohydrate metabolites provides new insights toward functional breeding in coffee. [PDF]

Plant Genome
Tavares Flores E, Spicer RL, Souza EMR, Ferrão MAG, Senra JFB, Azevedo C, Munoz PR, Tieman D, Voiniciuc C, Ferrão LFV.   +9 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Nanoparticle-Based Approaches for Enhancing In Vitro Fertilization in Animal Reproduction. [PDF]

Int J Mol Sci
Gałęska E, Kowalczyk A, Samardžija M, Gregurić Gračner G, Wrzecińska M, Araujo JP, Malagón JÁH, Camiña M, Czerniawska-Piątkowska E, Dobrzański Z.   +9 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Marker-Assisted Selection for Disease Resistance in Potato Breeding in the Ural Region of Russia (2018-2025): Comprehensive Genotyping and Validation of Key Resistance Markers. [PDF]

Int J Mol Sci
Lihodeevskiy GA, Shanina EP, Stafeeva MA, Akhmetkhanov VF, Shalaeva AV.   +4 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

From Shared Mechanisms to Precision Breeding: Engineering Cold and Drought Cross-Tolerance in Crops. [PDF]

Int J Mol Sci
Yang X, Jia ZC, Liu Y, Wang X, Chen JJ, Liu YG, Chen MX.   +6 more
europepmc   +1 more source