Results 121 to 130 of about 14,384,780 (329)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Filament L1482 in the California molecular cloud

, 2014
Aims. The process of gravitational fragmentation in the L1482 molecular filament of the California molecular cloud is studied by combining several complementary observations and physical estimates.
Esimbek, Jarken, He, Yu-Xin, Li, Da-Lei, Lou, Yu-Qing, Tang, Xin-Di, Wu, Gang, Zhou, Jian-Jun   +6 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Editorial: Application of advances in molecular and genetic researches to tackle pancreatic cancer: screening, diagnosis, prognostication and drug response prediction

Frontiers in Genetics, 2023
Salih Ibrahem, Saleh AlGhamdi
doaj   +1 more source

Mass spectra of Zc and Zb exotic states as hadron molecules

, 2015
We construct charmonium-like and bottomonium-like molecular interpolating currents with quantum numbers J(PC)=1(+-) in a systematic way, including both color singlet-singlet and color octet-octet structures.
Chen, Hua-Xing, Chen, Wei, Steele, T. G., Zhu, Shi-Lin   +3 more
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Global Collapses and Expansions in Star-Forming Clouds

, 2009
Spectral molecular line profile observations of star-forming molecular clouds sometimes show distinct red asymmetric double-peaked molecular line profiles with weaker blue peaks and stronger red peaks.
Adams, Adelson, Aguti, Arons, Belloche, Bernes, Bian, Carolan, Di Francesco, Evans, Fiege, Fiege, Fuller, Gao, Hammersley, Harvey, Hennebelle, Hogerheijde, Hu, Jørgensen, Kenyon, Keto, Lada, Larson, Lee, Lou, Lou, Lou, Lou, MacLow, Mardones, Matthews, Matzner, Matzner, McKee, Moraghan, Moriarty-Schieven, Myers, Myers, Nakano, Ossenkopf, Ostriker, Park, Park, Park, Rawlings, Redman, Redman, Saito, Schöier, Shang, Shen, Shirley, Shreider, Shu, Shu, Shu, Shu, Su, Tafalla, Tafalla, Tafalla, Thompson, Tsamis, van der Tak, Van Zadelhoff, Velusamy, Wang, Ward-Thompson, Wilner, Wu, Yang Gao, Yu, Yu, Yu-Qing Lou, Zhou, Zhou, Zweibel   +77 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source