Results 1 to 10 of about 1,822,561 (192)
Premise and peril of Wnt signaling activation through GSK-3β inhibition
iScience, 2022 Summary: Wnt signaling pathways have been extensively studied in the context of several diseases, including cancer, coronary artery disease, and age-related disorders.
Samuel M. Law, Jie J. Zheng
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iScience, 2021 Summary: Protein arginine methyltransferases (PRMTs) catalyze the post-translational monomethylation (Rme1), asymmetric (Rme2a), or symmetric (Rme2s) dimethylation of arginine. To determine the cellular consequences of type I (Rme2a) and II (Rme2s) PRMTs,
Maxim I. Maron +17 more
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Molecular biology of myeloma [PDF]
Clinical and Translational Oncology, 2007 Multiple myeloma (MM) is a B-cell malignancy characterised by the accumulation of clonal plasma cells (PC) in the bone marrow (BM). The molecular bases for this incurable disease have been widely investigated in the last years, and the development of modern genomic technologies has contributed to the understanding of the pathogenesis of MM.
Gutiérrez, Norma Carmen +2 more
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iScience, 2023 Summary: Low circulating phosphate (Pi) leads to rickets, characterized by expansion of the hypertrophic chondrocytes (HCs) in the growth plate due to impaired HC apoptosis.
Prem Swaroop Yadav +3 more
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The Molecular Biology of Ilarviruses
, 2013 Ilarviruses were among the first 16 groups of plant viruses approved by ICTV. Like Alfalfa mosaic virus (AMV), bromoviruses, and cucumoviruses they are isometric viruses and possess a single-stranded, tripartite RNA genome. However, unlike these other three groups, ilarviruses were recognized as being recalcitrant subjects for research (their ready ...
Pallás Benet, Vicente +4 more
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mTORC2 regulates auditory hair cell structure and function
iScience, 2023 Summary: mTOR broadly controls cell growth, but little is known about the role of mTOR complex 2 (mTORC2) in the inner ear. To investigate the role of mTORC2 in sensory hair cells (HCs), we generated HC-specific Rictor knockout (HC-RicKO) mice.
Maurizio Cortada +3 more
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The Application of Molecular Biology [PDF]
Current Issues in Molecular Biology, 1999 Molecular biology methods have tremendous value not only in the investigation of basic scientific questions, but also in application to a wide variety of problems affecting the overall human condition. Disease prevention and treatment, generation of new protein products, and manipulation of plants and animals for desired phenotypic traits are all ...
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STAR Protocols, 2023 Summary: The use of vascular-specific transgenic zebrafish provides advantages for identifying new mutations affecting angiogenesis and vascular development.
Juanjuan Luo +3 more
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iScience, 2022 Summary: Ribosome biogenesis (Ribi) is a complex and energy-consuming process, and should therefore be repressed under nutrient-limited conditions to minimize unnecessary cellular energy consumption. In yeast, the transcriptional repressors Dot6 and Tod6
Kino Kusama +7 more
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Molecular biology of erythropoietin
Kidney International, 1993 A 42-year-old man presented with hypertension and proteinuria 22 years ago and was found to have adult polycystic kidney disease. Within 8 years he was approaching end-stage renal failure (creatinine clearance, 10 mI/mm). The hemoglobin (Hb) was 10.0 g/dl. Hemodialysis was initiated 13 years ago, when his Hb was 6.6 g/dl. Two months later, it had risen
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