Results 21 to 30 of about 398,640 (265)

The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor

iScience, 2021
Summary: Arrestin-dependent activation of a G-protein-coupled receptor (GPCR) triggers endocytotic internalization of the receptor complex. We analyzed the interaction between the pattern recognition receptor (PRR) lectin-like oxidized low-density ...
Toshimasa Takahashi, Yibin Huang, Koichi Yamamoto, Go Hamano, Akemi Kakino, Fei Kang, Yuki Imaizumi, Hikari Takeshita, Yoichi Nozato, Satoko Nozato, Serina Yokoyama, Motonori Nagasawa, Tatsuo Kawai, Masao Takeda, Taku Fujimoto, Kazuhiro Hongyo, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Herbert Y. Gaisano, Tatsuya Sawamura, Hiromi Rakugi   +23 more
doaj   +1 more source

miR-29cb2 promotes angiogenesis and osteogenesis by inhibiting HIF-3α in bone

iScience, 2022
Summary: Coordination between osteogenesis and angiogenesis is required for bone homeostasis. Here, we show that miR-29cb2 is a bone-specific miRNA and plays critical roles on angiogenesis-osteogenesis coupling during bone remodeling.
Liping Ouyang, Yingxiao Sun, Dan Lv, Xiaochun Peng, Xiaoming Liu, Lei Ci, Guoning Zhang, Bo Yuan, Ling Li, Jian Fei, Jun Ma, Xuanyong Liu, Yun Liao   +12 more
doaj   +1 more source

mTORC2 regulates auditory hair cell structure and function

iScience, 2023
Summary: mTOR broadly controls cell growth, but little is known about the role of mTOR complex 2 (mTORC2) in the inner ear. To investigate the role of mTORC2 in sensory hair cells (HCs), we generated HC-specific Rictor knockout (HC-RicKO) mice.
Maurizio Cortada, Soledad Levano, Michael N. Hall, Daniel Bodmer   +3 more
doaj   +1 more source

Formal molecular biology

Theoretical Computer Science, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
DANOS V., LANEVE, COSIMO
openaire   +1 more source

Molecular biology of the gut [PDF]

Molecular and Cellular Pediatrics, 2016
Editorial The gastrointestinal tract is the largest exposed surface among mammalian macroorganisms. It is constantly exposed to substantial challenges and exerts a potpourri of diverse physiological functions. Among the major intestinal functions is the digestion of nutrients and subsequent uptake and metabolism of their respective building blocks ...
Naim, Hassan Y., Zimmer, Klaus-Peter, Nichols, Buford   +2 more
openaire   +2 more sources

Towards molecular systems biology of gene transcription and regulation [PDF]

, 2010
Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, P., Cramer, Patrick
core   +1 more source

Implications of Big Data for cell biology

, 2015
“Big Data” has surpassed “systems biology” and “omics” as the hottest buzzword in the biological sciences, but is there any substance behind the hype? Certainly, we have learned about various aspects of cell and molecular biology from the many individual
Dolinski, Kara, Troyanskaya, Olga
core   +1 more source

Dot6/Tod6 degradation fine-tunes the repression of ribosome biogenesis under nutrient-limited conditions

iScience, 2022
Summary: Ribosome biogenesis (Ribi) is a complex and energy-consuming process, and should therefore be repressed under nutrient-limited conditions to minimize unnecessary cellular energy consumption. In yeast, the transcriptional repressors Dot6 and Tod6
Kino Kusama, Yuta Suzuki, Ena Kurita, Tomoyuki Kawarasaki, Keisuke Obara, Fumihiko Okumura, Takumi Kamura, Kunio Nakatsukasa   +7 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

The Philosophy of Molecular and Developmental Biology [PDF]

, 2000
Philosophical discussion of molecular and developmental biology began in the late 1960s with the use of genetics as a test case for models of theory reduction.
Griffiths, Paul Edmund
core