Results 11 to 20 of about 3,456,075 (306)

A New Open Access Journal: Molecular Biology & Nanomedicine [PDF]

Molecular Biology & Nanomedicine, 2020
The new open access journal Molecular Biology & Nanomedicine (MBN) is published by Techland Publishing Group. Techland Publishing, founded in Hongkong in December 2019, is an international publishing company focusing on open access academic publishing ...
Molecular Biology & Nanomedicine Editorial Office
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Non-Darwinian Molecular Biology

Frontiers in Genetics, 2022
With the discovery of the double helical structure of DNA, a shift occurred in how biologists investigated questions surrounding cellular processes, such as protein synthesis. Instead of viewing biological activity through the lens of chemical reactions,
Alexander F. Palazzo, Nevraj S. Kejiou
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Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function

iScience, 2021
Summary: Deficiency of the serine hydrolase prolyl endopeptidase-like (PREPL) causes a recessive metabolic disorder characterized by neonatal hypotonia, feeding difficulties, and growth hormone deficiency.
Karen Rosier, Molly T. McDevitt, Joél Smet, Brendan J. Floyd, Maxime Verschoore, Maria J. Marcaida, Craig A. Bingman, Irma Lemmens, Matteo Dal Peraro, Jan Tavernier, Benjamin F. Cravatt, Natalia V. Gounko, Katlijn Vints, Yenthe Monnens, Kritika Bhalla, Laetitia Aerts, Edrees H. Rashan, Arnaud V. Vanlander, Rudy Van Coster, Luc Régal, David J. Pagliarini, John W.M. Creemers   +21 more
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Conditional deletion of LRRC8A in the brain reduces stroke damage independently of swelling-activated glutamate release

iScience, 2023
Summary: The ubiquitous volume-regulated anion channels (VRACs) facilitate cell volume control and contribute to many other physiological processes. Treatment with non-specific VRAC blockers or brain-specific deletion of the essential VRAC subunit LRRC8A
Mustafa Balkaya, Preeti Dohare, Sophie Chen, Alexandra L. Schober, Antonio M. Fidaleo, Julia W. Nalwalk, Rajan Sah, Alexander A. Mongin   +7 more
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Asymmetric inheritance of RNA toxicity in C. elegans expressing CTG repeats

iScience, 2022
Summary: Nucleotide repeat expansions are a hallmark of over 40 neurodegenerative diseases and cause RNA toxicity and multisystemic symptoms that worsen with age.
Maya Braun, Shachar Shoshani, Joana Teixeira, Anna Mellul Shtern, Maya Miller, Zvi Granot, Sylvia E.J. Fischer, Susana M.D. A. Garcia, Yuval Tabach   +8 more
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Histone deacetylation regulates nucleotide excision repair through an interaction with the XPC protein

iScience, 2022
Summary: The XPC protein complex plays a central role in DNA lesion recognition for global genome nucleotide excision repair (GG-NER). Lesion recognition can be accomplished in either a UV-DDB-dependent or -independent manner; however, it is unclear how ...
Masayuki Kusakabe, Erina Kakumu, Fumika Kurihara, Kazuki Tsuchida, Takumi Maeda, Haruto Tada, Kanako Kusao, Akari Kato, Takeshi Yasuda, Tomonari Matsuda, Mitsuyoshi Nakao, Masayuki Yokoi, Wataru Sakai, Kaoru Sugasawa   +13 more
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TGFβ2 and TGFβ3 mediate appropriate context-dependent phenotype of rat valvular interstitial cells

iScience, 2021
Summary: This study focused on characterizing the potential mechanism of valvular toxicity caused by TGFβ receptor inhibitors (TGFβRis) using rat valvular interstitial cells (VICs) to evaluate early biological responses to TGFβR inhibition. Three TGFβRis
Faye Wang, Cindy Zhang, Jae Kwagh, Brian Strassle, Jinqing Li, Minxue Huang, Yunling Song, Brenda Lehman, Richard Westhouse, Kamalavenkatesh Palanisamy, Vinay K. Holenarsipur, Robert Borzilleri, Karen Augustine-Rauch   +12 more
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Missense mutations in inositol 1,4,5-trisphosphate receptor type 3 result in leaky Ca2+ channels and activation of store-operated Ca2+ entry

iScience, 2022
Summary: Mutations in all subtypes of the inositol 1,4,5-trisphosphate receptor Ca2+ release channel are associated with human diseases. In this report, we investigated the functionality of three neuropathy-associated missense mutations in IP3R3 (V615M ...
Lara E. Terry, Vikas Arige, Julika Neumann, Amanda M. Wahl, Taylor R. Knebel, James W. Chaffer, Sundeep Malik, Adrian Liston, Stephanie Humblet-Baron, Geert Bultynck, David I. Yule   +10 more
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New binding specificities evolve via point mutation in an invertebrate allorecognition gene

iScience, 2021
Summary: Many organisms use genetic self-recognition systems to distinguish themselves from conspecifics. In the cnidarian, Hydractinia symbiolongicarpus, self-recognition is partially controlled by allorecognition 2 (Alr2).
Aidan L. Huene, Traci Chen, Matthew L. Nicotra   +2 more
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Correction: Ten simple rules for leveraging virtual interaction to build higher-level learning into bioinformatics short courses.

PLoS Computational Biology, 2023
[This corrects the article DOI: 10.1371/journal.pcbi.1010220.].
Wendi Bacon, Alexandra Holinski, Marina Pujol, Meredith Wilmott, Sarah L Morgan, European Molecular Biology Laboratory—European Bioinformatics Institute Training Team   +5 more
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