Results 11 to 20 of about 1,932,786 (265)

Molecular Radiation Biology

, 2023
AbstractVarious exogeneous and endogenous factors constantly cause damages in the biomolecules within a cell. For example, per day, 10,000–100,000 molecular lesions occur in DNA per cell. The molecule modifications that are formed disturb the structure and function of the affected molecules.
Reindl, Judith, Abrantes, Ana Margarida, Ahire, Vidhula, Azimzadeh, Omid, Baatout, Sarah, Baeyens, Ans, Baselet, Bjorn, Chauhan, Vinita, Da Pieve, Fabiana, Delbart, Wendy, Dobney, Caitlin Pria, Edin, Nina Frederike Jeppesen, Falk, Martin, Foray, Nicolas, François, Agnès, Frelon, Sandrine, Gaipl, Udo S., Georgakilas, Alexandros G., Guipaud, Olivier, Hausmann, Michael, Michaelidesova, Anna Jelinek, Kadhim, Munira, Marques, Inês Alexandra, Milic, Mirta, Mistry, Dhruti, Moertl, Simone, Montoro, Alegría, Obrador, Elena, Pires, Ana Salomé, Quintens, Roel, Rajan, Nicholas, Rödel, Franz, Rogan, Peter, Savu, Diana, Schettino, Giuseppe, Tabury, Kevin, Terzoudi, Georgia I., Triantopoulou, Sotiria, Viktorsson, Kristina, Wozny, Anne-Sophie   +39 more
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Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases

iScience, 2021
Summary: Protein arginine methyltransferases (PRMTs) catalyze the post-translational monomethylation (Rme1), asymmetric (Rme2a), or symmetric (Rme2s) dimethylation of arginine. To determine the cellular consequences of type I (Rme2a) and II (Rme2s) PRMTs,
Maxim I. Maron, Stephanie M. Lehman, Sitaram Gayatri, Joseph D. DeAngelo, Subray Hegde, Benjamin M. Lorton, Yan Sun, Dina L. Bai, Simone Sidoli, Varun Gupta, Matthew R. Marunde, James R. Bone, Zu-Wen Sun, Mark T. Bedford, Jeffrey Shabanowitz, Hongshan Chen, Donald F. Hunt, David Shechter   +17 more
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Premise and peril of Wnt signaling activation through GSK-3β inhibition

iScience, 2022
Summary: Wnt signaling pathways have been extensively studied in the context of several diseases, including cancer, coronary artery disease, and age-related disorders.
Samuel M. Law, Jie J. Zheng
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Molecular Biology

Revista do Instituto de Medicina Tropical de São Paulo, 2003
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Cytoplasmic and mitochondrial aminoacyl-tRNA synthetases differentially regulate lifespan in Caenorhabditis elegans

iScience, 2022
Summary: Reducing the rate of translation promotes longevity in multiple organisms, representing a conserved mechanism for lifespan extension. Aminoacyl-tRNA synthetases (ARSs) catalyze the loading of amino acids to their cognate tRNAs, thereby playing ...
Tianlin Zheng, Qiang Luo, Chengxuan Han, Jiejun Zhou, Jianke Gong, Lei Chun, X.Z. Shawn Xu, Jianfeng Liu   +7 more
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Regulatory Molecular Biology [PDF]

Cell Cycle, 2006
Close regulations of molecular biological processes are essential for life. Defective controls cause diseases such as cancer and neurological malfunctions. We now are provided with a plethora of regulatory mechanisms exerted at many levels. Prominent are covalent protein modifications, non-covalent feedback inhibition that modifies enzyme activity, and
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RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11

iScience, 2022
Summary: How the ataxia telangiectasia mutated (ATM) protein kinase, a core protein in DNA damage response, is regulated at post-transcription level remains unclear.
Yarui Zhang, Guomin Ou, Zhujing Ye, Zhou Zhou, Qianlin Cao, Mengting Li, Jingdong Wang, Jianping Cao, Hongying Yang   +8 more
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Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes

iScience, 2023
Summary: Low circulating phosphate (Pi) leads to rickets, characterized by expansion of the hypertrophic chondrocytes (HCs) in the growth plate due to impaired HC apoptosis.
Prem Swaroop Yadav, Garyfallia Papaioannou, Margaret M. Kobelski, Marie B. Demay   +3 more
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Protocol for generating mutant zebrafish using CRISPR-Cas9 followed by quantitative evaluation of vascular formation

STAR Protocols, 2023
Summary: The use of vascular-specific transgenic zebrafish provides advantages for identifying new mutations affecting angiogenesis and vascular development.
Juanjuan Luo, Chunjiao Lu, Maya Wang, Xiaojun Yang   +3 more
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Molecular biology of hearing [PDF]

Laryngo- rhino- otologie, 2011
GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 10:Doc06; ISSN 1865 ...
Stöver, Timo, Diensthuber, Marc
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