Results 31 to 40 of about 1,822,561 (192)

Establishment of a primary porcine retinal pigment epithelium monolayer to complement retinal ex vivo cultures

open access: yesSTAR Protocols, 2023
Summary: Impaired function of the retinal pigment epithelium (RPE) resembles a hallmark in many retinal diseases; thus, co-cultivation models with RPE and retinal explants are useful to investigate these.
Agnes Fietz   +3 more
doaj  

Molecular biology of neuroblastoma

open access: yesClinical and Translational Oncology, 2007
Neuroblastoma is one of the most frequently occurring solid tumours in children, especially in the first year of life, when it accounts for 50% of all tumours. It is the second most common cause of death in children, only preceded by accidents. The most peculiar characteristic of neuroblastoma is its clinical heterogeneity.
Elena Grau   +3 more
openaire   +3 more sources

A Haspin-ARHGAP11A axis regulates epithelial morphogenesis through Rho-ROCK dependent modulation of LIMK1-Cofilin

open access: yesiScience, 2023
Summary: Throughout mitosis, a plethora of processes must be efficiently concerted to ensure cell proliferation and tissue functionality. The mitotic spindle does not only mediate chromosome segregation, but also defines the axis of cellular division ...
Roberto Quadri   +6 more
doaj  

eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance

open access: yesiScience, 2023
Summary: The mRNA cap-binding protein, eukaryotic initiation factor 4E (eIF4E), is crucial for translation and regulated by Ser209 phosphorylation. However, the biochemical and physiological role of eIF4E phosphorylation in translational control of long ...
Sudarshan Patil   +7 more
doaj  

Intracellular TMEM16A is necessary for myogenesis of skeletal muscle

open access: yesiScience, 2022
Summary: Transmembrane protein 16A (TMEM16A) localizes at plasma membrane and controls chloride influx in various type of cells. We here showed an intracellular localization pattern of TMEM16A molecules.
Wen Yuan   +14 more
doaj  

Evaluation of colloidal platinum on cytotoxicity, oxidative stress and barrier permeability across the gut epithelium

open access: yesHeliyon, 2019
Colloidal platinum (Pt) is widely consumed due to its health promoting benefits. However, the exact biological effects of these nanoparticles have not been studied in detail, particularly in the gut. In the present study we observed that colloidal Pt was
Sinem Tunçer   +5 more
doaj  

A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling

open access: yesiScience, 2023
Summary: Stem cells (SCs) are critical to maintain tissue homeostasis. However, it is currently not known whether signaling through cell junctions protects quiescent epithelial SC reservoirs from depletion during disease-inflicted damage.
William V.J. Hariton   +11 more
doaj  

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