Bioinformatics Databases: State of the Art and Research Perspectives [PDF]
Bioinformatics or computational biology, i.e. the application of mathematical and computer science methods to solving problems in molecular biology that require large scale data, computation, and analysis, is a research area currently receiving a ...
Bry, François, Kröger, Peer
core +2 more sources
The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor
Summary: Arrestin-dependent activation of a G-protein-coupled receptor (GPCR) triggers endocytotic internalization of the receptor complex. We analyzed the interaction between the pattern recognition receptor (PRR) lectin-like oxidized low-density ...
Toshimasa Takahashi +23 more
doaj +1 more source
Natural history of Arabidopsis thaliana and oomycete symbioses [PDF]
Molecular ecology of plant–microbe interactions has immediate significance for filling a gap in knowledge between the laboratory discipline of molecular biology and the largely theoretical discipline of evolutionary ecology.
A. Falk +87 more
core +2 more sources
miR-29cb2 promotes angiogenesis and osteogenesis by inhibiting HIF-3α in bone
Summary: Coordination between osteogenesis and angiogenesis is required for bone homeostasis. Here, we show that miR-29cb2 is a bone-specific miRNA and plays critical roles on angiogenesis-osteogenesis coupling during bone remodeling.
Liping Ouyang +12 more
doaj +1 more source
My career in molecular biology [PDF]
Norman Davidson's training as a physical chemist led him to make key early contributions to the chemistry of DNA. He described the details of DNA denaturation and renaturation, concepts that still form the basis for understanding hybridization.
Davidson, Norman
core +1 more source
mTORC2 regulates auditory hair cell structure and function
Summary: mTOR broadly controls cell growth, but little is known about the role of mTOR complex 2 (mTORC2) in the inner ear. To investigate the role of mTORC2 in sensory hair cells (HCs), we generated HC-specific Rictor knockout (HC-RicKO) mice.
Maurizio Cortada +3 more
doaj +1 more source
Developing Predictive Molecular Maps of Human Disease through Community-based Modeling [PDF]
The failure of biology to identify the molecular causes of disease has led to disappointment in the rate of development of new medicines. By combining the power of community-based modeling with broad access to large datasets on a platform that promotes ...
Christine Suver +10 more
core +2 more sources
Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease [PDF]
Copyright © 2015, The American Society for Biochemistry and Molecular Biology. Acknowledgements-We thank Drs Timo Rager and Rolf Hilfiker (Solvias, Switzerland) for polymorph analyses.Peer reviewedPublisher ...
Clunas, Scott +14 more
core +1 more source
NaviCell: a web-based environment for navigation, curation and maintenance of large molecular interaction maps [PDF]
Molecular biology knowledge can be systematically represented in a computer-readable form as a comprehensive map of molecular interactions. There exist a number of maps of molecular interactions containing detailed description of various cell mechanisms.
Barillot, Emmanuel +6 more
core +4 more sources
Engineers and biologists are using sound to mix fluids, move cells, and dispense liquids. Nathan Blow looks at how acoustic science is changing molecular biology and high-throughput screening.
Nathan Blow
doaj +1 more source

