Results 41 to 50 of about 507,440 (288)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Epistatic interaction has the reverse effects with its constitutive quantitative trait loci

Scientific Reports
Epistasis is one of important genetic components for a quantitative trait in plant. Eshed and Zamir found negative epistatic interactions of quantitative trait loci in Tomato first.
Yuanyuan Liu, Bihuang Zhu, Jichun Tang, Lilong Huang, Guodong Chen, Leyi Chen, Suhong Bu, Haitao Zhu, Zupei Liu, Zhan Li, Lijun Meng, Guifu Liu, Shaokui Wang   +12 more
doaj   +1 more source

Diversity, genetic mapping, and signatures of domestication in the carrot (Daucus carota L.) genome, as revealed by Diversity Arrays Technology (DArT) markers [PDF]

, 2013
Carrot is one of the most economically important vegetables worldwide, but genetic and genomic resources supporting carrot breeding remain limited. We developed a Diversity Arrays Technology (DArT) platform for wild and cultivated carrot and used it to ...
Allender, Charlotte J., Baranski, Rafal, Cavagnaro, Pablo, Ellison, Shelby, Grzebelus, Dariusz, Heller-Uszynska, Kasia, Iorizzo, Massimo, Kilian, Andrzej, Macko-Podgorni, Alicja, Nothnagel, Thomas, Senalik, Douglas, Simon, P. W. (Philipp W.)   +11 more
core   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

QTL epistasis plays a role of homeostasis on heading date in rice

Scientific Reports
If there was no gene interaction, the gene aggregation effect would increase infinitely with the increase of gene number. Epistasis avoids the endless accumulation of gene effects, playing a role of homeostasis.
Lilong Huang, Jichun Tang, Bihuang Zhu, Guodong Chen, Leyi Chen, Suhong Bu, Haitao Zhu, Zupei Liu, Zhan Li, Lijun Meng, Guifu Liu, Shaokui Wang   +11 more
doaj   +1 more source

Essentially Derived Varieties in Ornamentals [PDF]

, 2009
The concept of Essentially derived varieties (EDVs) was introduced in the UPOV 1991 act to protect the interests of the breeder of the initial variety. When a variety is considered as an EDV, authorisation for commercial exploitation is needed from the ...
Vosman, B.
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Genome-wide characterization of AhBAG genes in peanut reveals their role in bacterial wilt resistance and hormone response

BMC Plant Biology
Background The BAG gene family, encoding Bcl-2-associated anti-apoptotic proteins, plays pivotal roles in regulating plant growth, development, and stress responses.
Kai Zhao, Yanzhe Li, Jinzhi Wang, Yue Tu, Zenghui Cao, Xingli Ma, Fangping Gong, Zhongfeng Li, Lin Zhang, Ding Qiu, Xingguo Zhang, Rui Ren, Kunkun Zhao, Dongmei Yin   +13 more
doaj   +1 more source

Development of EST derived-SSRs of Theobroma grandiflorum for molecular breeding : S04P05 [PDF]

, 2013
Simple sequence repeats (SSRs) markers are widely used in breeding programs, and SSRs associated to expressed sequence tags (ESTs) could be quite efficient in the selection of genotypes of interest.
Alves, Rafael Moyses, Falcão, Loeni Ludke, Gramacho, Karina Peres, Marcellino, Lucilia Helena, Micheli, Fabienne, Moreira, R.F., Santos, L.F., Silva-Werneck, Joseilde Oliveira   +7 more
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source