Results 181 to 190 of about 147,841 (291)

Plasmodium falciparum Molecular Chaperones: Guardians of the Malaria Parasite Proteome and Renovators of the Host Proteome. [PDF]

Front Cell Dev Biol, 2022
Blatch GL.
europepmc   +1 more source

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

Epilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden, Verena Buchecker, Amelie Wagner, Victoria M. Stocker, Liga Zvejniece, Heidrun Potschka   +5 more
wiley   +1 more source

Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones. [PDF]

mBio, 2022
Zuily L, Lahrach N, Fassler R, Genest O, Faller P, Sénèque O, Denis Y, Castanié-Cornet MP, Genevaux P, Jakob U, Reichmann D, Giudici-Orticoni MT, Ilbert M.   +12 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes. [PDF]

Sci Adv, 2023
Sun Y, Papadaki GF, Devlin CA, Danon JN, Young MC, Winters TJ, Burslem GM, Procko E, Sgourakis NG.   +8 more
europepmc   +1 more source

Artificial intelligence in the assessment of epilepsy‐related genetic mutations: Learned from GABAA receptors and GABA transporter 1

Epilepsia Open, EarlyView.
Abstract This review examines how recent genetic and technological advances have transformed our understanding and treatment of genetic epilepsies (GEs), with a focus on disorders involving GABAA receptors (GABRs) and the GABA transporter 1 (GAT‐1) encoded by SLC6A1.
Juexin Wang, Jing‐Qiong Kang
wiley   +1 more source

A widespread family of molecular chaperones promotes the intracellular stability of type VIIb secretion system-exported toxins. [PDF]

Proc Natl Acad Sci U S A
Gkragkopoulou P, Garrett SR, Shah PY, Grebenc DW, Klein TA, Kim Y, Whitney JC.   +6 more
europepmc   +1 more source

Molecular Chaperones in Osteosarcoma: Diagnosis and Therapeutic Issues. [PDF]

Cells, 2021
Lallier M, Marchandet L, Moukengue B, Charrier C, Baud'huin M, Verrecchia F, Ory B, Lamoureux F.   +7 more
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Developing nanobodies as allosteric molecular chaperones of glucocerebrosidase function. [PDF]

Nat Commun
Dal Maso T, Sinisgalli C, Zilio G, Franzin E, Tessari I, Pardon E, Steyaert J, Ballet S, Greggio E, Versées W, Plotegher N.   +10 more
europepmc   +1 more source