Results 11 to 20 of about 146,944 (294)

Molecular chaperones in stroke-induced immunosuppression [PDF]

Neural Regeneration Research, 2023
Stroke-induced immunosuppression is a process that leads to peripheral suppression of the immune system after a stroke and belongs to the central nervous system injury-induced immunosuppressive syndrome.
Haoduo Qiao, Qing Xu, Yunfei Xu, Yao Zhao, Nina He, Jie Tang, Jie Zhao, Ying Liu   +7 more
doaj   +2 more sources

Advances in the structures, mechanisms and targeting of molecular chaperones [PDF]

Signal Transduction and Targeted Therapy
Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention of protein misfolding and abnormal aggregation, the modulation of protein homeostasis, and the protection of cells from damage under constantly ...
Jinying Gu, Yanyi He, Chenxi He, Qiuyue Zhang, Qifei Huang, Shangjun Bai, Ruoning Wang, Qidong You, Lei Wang   +8 more
doaj   +2 more sources

Redefining Molecular Chaperones as Chaotropes [PDF]

Frontiers in Molecular Biosciences, 2021
Molecular chaperones are the key instruments of bacterial protein homeostasis. Chaperones not only facilitate folding of client proteins, but also transport them, prevent their aggregation, dissolve aggregates and resolve misfolded states.
Jakub Macošek, Guillaume Mas, Sebastian Hiller   +2 more
doaj   +2 more sources

Beneficial Handling of Molecular Chaperones (Chaperonotherapy) in Glioblastoma and Neuroblastoma: Novel Therapeutic Targets or Potential Agents? [PDF]

Cells
Molecular chaperones, especially Heat Shock Proteins (HSPs), play complex, context-dependent roles in cancer, particularly in nervous system (NS) tumors like glioblastoma (GBM) and neuroblastoma (NB).
Maria Antonella Augello, Nima Shadan, Giuseppa D’Amico, Rosario Barone, Celeste Caruso Bavisotto, Federica Scalia, Alessandra Maria Vitale   +6 more
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Editorial: Molecular Chaperones and Neurodegeneration [PDF]

Frontiers in Neuroscience, 2017
Peer ...
Cintia Roodveldt, Tiago F. Outeiro, Janice E. A. Braun   +2 more
doaj   +8 more sources

Mitochondrial molecular chaperones [PDF]

, 1994
After synthesis in the cytosol, most mitochondrial proteins must traverse mitochondrial membranes to reach their functional location. During this process, proteins become unfolded and then refold to attain their native conformation after crossing the ...
Atencio, Caplan, Caplan, Cheng, Craig, Cyr, Deshales, Eilers, Gambill, Glick, Glick, Hartl, Hartl, Hwang, Johnson, Kang, Kiebler, Langer, Liberek, Manning-Krieg, Neupert, Ostermann, Palleros, Rassow, Rospert, Sanders, Scherer, Schleyer, Schröder, Simon, Vestweber, Voos, Xia   +32 more
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Editorial: Molecular chaperones and human disease [PDF]

Frontiers in Molecular Biosciences, 2022
Graham Chakafana, Stanley Makumire, Xolani Henry Makhoba   +2 more
doaj   +2 more sources

Editorial: Molecular chaperones and polyamines in disease [PDF]

Frontiers in Molecular Biosciences
Stanley Makumire, Graham Chakafana, Xolani H. Makhoba   +2 more
doaj   +2 more sources

Molecular chaperones and Parkinson's disease

Neurobiology of Disease, 2021
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive death of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies (LBs). Mutations in PD-related genes lead to neuronal pathogenesis through various
Shenglan Hu, Jieqiong Tan, Lixia Qin, Lingling Lv, Weiqian Yan, Hainan Zhang, BeiSha Tang, Chunyu Wang   +7 more
doaj   +1 more source

Targeting Chaperone/Co-Chaperone Interactions with Small Molecules: A Novel Approach to Tackle Neurodegenerative Diseases

Cells, 2021
The dysfunction of the proteostasis network is a molecular hallmark of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Molecular chaperones are a major component of the
Lisha Wang, Liza Bergkvist, Rajnish Kumar, Bengt Winblad, Pavel F. Pavlov   +4 more
doaj   +1 more source