CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target
Advanced Science, EarlyView.This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang +2 more
wiley +1 more source
Molecular chaperones HSP40, HSP70, STIP1, and HSP90 are involved in stabilization of Cx43. [PDF]
Cytotechnology, 2023 An L +15 more
europepmc +1 more source
Characterisation of novel extracellular molecular chaperones and their effects on amyloid formation
, 2007 Justin J. Yerbury
openalex +2 more sources
A nucleolar protein allows viability in the absence of the essential ER-residing molecular chaperone calnexin [PDF]
, 2009 Pascale B. Beauregard +4 more
openalex +1 more source
Advanced Science, EarlyView.This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang +7 more
wiley +1 more source
Expression and characterisation of human glycerol kinase: the role of solubilising agents and molecular chaperones. [PDF]
Biosci Rep, 2023 Rani RM, Syngkli S, Nongkhlaw J, Das B.
europepmc +1 more source
Advanced Science, EarlyView.This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang +5 more
wiley +1 more source
Improved Production of Recombinant Carboxylesterase FumDM by Co-Expressing Molecular Chaperones in Pichia pastoris. [PDF]
Toxins (Basel), 2023 Jiang L +6 more
europepmc +1 more source
Adhesin presentation in bacteria requires molecular chaperones and ushers [PDF]
, 1992 C. Hal Jones +6 more
openalex +1 more source
ROLE OF CHAPERONES IN HEALTHY BOWEL AND IBD. [PDF]
, 2015 The chaperoning system is the wole complement of chaperones, co-chaperones and chaperone cofactors of the body that preserves cell and tissue homeostasis.
CAPPELLO, Francesco +6 more
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