Results 21 to 30 of about 4,011,919 (357)

Genetic polymorphisms of Ca²⁺ transport proteins and molecular chaperones in mitochondria-associated endoplasmic reticulum membrane and non-alcoholic fatty liver disease. [PDF]

Front Endocrinol (Lausanne), 2022
Tang Z, Ding Y, Zhang R, Zhang M, Guan Q, Zhang L, Wang H, Chen Y, Jiang R, Zhang W, Wang J.   +10 more
europepmc   +3 more sources

Targeting Chaperone/Co-Chaperone Interactions with Small Molecules: A Novel Approach to Tackle Neurodegenerative Diseases

Cells, 2021
The dysfunction of the proteostasis network is a molecular hallmark of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Molecular chaperones are a major component of the
Lisha Wang, Liza Bergkvist, Rajnish Kumar, Bengt Winblad, Pavel F. Pavlov   +4 more
doaj   +1 more source

Modulation of protein fate decision by small molecules: targeting molecular chaperone machinery

Acta Pharmaceutica Sinica B, 2020
Modulation of protein fate decision and protein homeostasis plays a significant role in altering the protein level, which acts as an orientation to develop drugs with new mechanisms.
Lei Wang, Xiaoli Xu, Zhengyu Jiang, Qidong You   +3 more
doaj   +1 more source

The Chemical Biology of Molecular Chaperones—Implications for Modulation of Proteostasis

Journal of Molecular Biology, 2015
Kristoffer Brandvold, Richard I. Morimoto   +1 more
openalex   +2 more sources

Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]

, 2008
The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
Argent, Argent, Arndt, Brodsky, Brodsky, C. Rogon, Chaddock, Chen, Hudson, Hundley, H  hfeld, J. Hohfeld, J. M. Lord, J. P. Cook, L. M. Roberts, Lawson, Luders, Meacham, Meusser, Nakatsukasa, Nakatsukasa, P. J. Hart, P. Pietroni, R. A. Spooner, Rapak, Roe, Savino, Spooner, Urushitani, van Deurs, Wales, Wesche, Younger   +32 more
core   +4 more sources

Molecular Chaperones: Molecular Assembly Line Brings Metabolism and Immunity in Shape

Metabolites, 2020
Molecular chaperones are a set of conserved proteins that have evolved to assist the folding of many newly synthesized proteins by preventing their misfolding under conditions such as elevated temperatures, hypoxia, acidosis and nutrient deprivation ...
Haoxin Zhao, Lydia N. Raines, Stanley Ching-Cheng Huang   +2 more
doaj   +1 more source

Molecular Chaperone Receptors [PDF]

, 2017
Extracellular heat shock proteins (HSP) play important roles in cell signaling and immunity. Many of these effects are mediated by surface receptors expressed on a wide range of cell types. We have investigated the nature of such proteins by cloning candidate receptors into cells (CHO-K1) with the rare property of being null for HSP binding. Using this
Ayesha, Murshid, Jimmy, Theriault, Jianlin, Gong, Stuart K, Calderwood   +3 more
openaire   +2 more sources

Recent advances in understanding catalysis of protein folding by molecular chaperones

FEBS Letters, 2020
Molecular chaperones are highly conserved proteins that promote proper folding of other proteins in vivo. Diverse chaperone systems assist de novo protein folding and trafficking, the assembly of oligomeric complexes, and recovery from stress‐induced ...
D. Balchin, M. Hayer-Hartl, F. Hartl
semanticscholar   +1 more source

Human molecular chaperones share with SARS-CoV-2 antigenic epitopes potentially capable of eliciting autoimmunity against endothelial cells: possible role of molecular mimicry in COVID-19

Cell stress & chaperones (Print), 2020
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), the cause of COVID-19 disease, has the potential to elicit autoimmunity because mimicry of human molecular chaperones by viral proteins.
A. Marino Gammazza, Sébastien Légaré, Giosuè Lo Bosco, A. Fucarino, F. Angileri, E. Conway de Macario, A. Macario, F. Cappello   +7 more
semanticscholar   +1 more source

Molecular Chaperones: A Double-Edged Sword in Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2020
Aberrant accumulation of misfolded proteins into amyloid deposits is a hallmark in many age-related neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis ...
Jessica Tittelmeier, Eliana Nachman, Carmen Nussbaum‐Krammer   +2 more
semanticscholar   +1 more source