Results 121 to 130 of about 23,771 (149)
A Universal Biomimetic Approach for Making Artificial Antigen‐Presenting Cells for T Cell Activation
Advanced Functional Materials, EarlyView.This study shows a biomimetic silica microcapsule (SMC) fabrication method under mild conditions for making artificial antigen‐presenting cells (aAPCs). Inspired by marine biomineralization, peptide‐mediated biosilicification enables silica shell formation on emulsion templates. The resulting SMCs possess a core–shell structure, controlled fluorescence
Fei Hou +5 more
wiley +1 more source
Molecular cloning of a human histocompatibility antigen cDNA fragment.
, 1980 Hidde L. Ploegh +2 more
openalex +1 more source
Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction
Advanced Healthcare Materials, EarlyView.This study develops a graft‐host skeletal muscle assembloid model combining neuromuscular organoids with tissue‐engineered constructs. Pre‐seeding decellularized muscles with myogenic cells enhances cell migration and axon invasion from the organoid. The model exhibits regenerative capacity following acute damage, advancing the understanding of human ...
Lucia Rossi +13 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner +5 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Melanoma cell spheroid engraftment is optimized in the chicken chorioallantoic membrane overcoming the complexity of other in vivo models. Using this model, greater penetration of cerium oxide nanoparticles (nanoceria) functionalized with heparin in spheroids is observed via enhancement of vascularization than nanoceria alone.
Lu Fu +5 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This study develops itaconate‐based polymer microparticles (IA‐MPs) for macrophage‐targeted intracellular delivery, overcoming the limitations of traditional itaconate administration. IA‐MPs achieve controlled release through phagocytosis, reducing pro‐inflammatory cytokine expression and reprogramming macrophage metabolism toward glycolysis.
Kaitlyn E. Woodworth +10 more
wiley +1 more source
High‐Resolution Patterned Delivery of Chemical Signals From 3D‐Printed Picoliter Droplet Networks
Advanced Materials, EarlyView.3D‐printed picoliter droplet networks have been fabricated that control gene expression in bacterial populations by releasing chemical signals with precise spatial definition and high temporal resolution. This system of effector release is widely applicable, offering diverse applications in biology and medicine.
Jorin Riexinger +7 more
wiley +1 more source
Advanced Materials, EarlyView.Stem cell spheroids, produced via a high‐throughput microfabrication technique, are transported within a vortex generated at the outlet channels of a cross‐slot millifluidic chip. For Reynolds number exceeding 170–200, intermittent high shear stresses applied to each spheroid within the vortex trigger a massive release of biologically active ...
Elliot Thouvenot +8 more
wiley +1 more source