Results 91 to 100 of about 653,689 (278)
Membrane identity and GTPase cascades regulated by toggle and cut‐out switches
Molecular Systems Biology, 2008 Key cellular functions and developmental processes rely on cascades of GTPases. GTPases of the Rab family provide a molecular ID code to the generation, maintenance and transport of intracellular compartments.
Perla Del Conte‐Zerial +6 more
doaj +1 more source
Toward bio-inspired information processing with networks of nano-scale switching elements
, 2013 Unconventional computing explores multi-scale platforms connecting molecular-scale devices into networks for the development of scalable neuromorphic architectures, often based on new materials and components with new functionalities. We review some work
Konkoli, Zoran, Wendin, Göran
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Advanced SciencePartial differential equations, essential for modeling dynamic systems, persistently confront computational complexity bottlenecks in high‐dimensional problems, yet DNA‐based parallel computing architectures, leveraging their discrete mathematics merits,
Yijun Xiao +5 more
doaj +1 more source
The Scientific World Journal, 2014 A complex computing problem can be solved efficiently on a system with multiple computing nodes by dividing its implementation code into several parallel processing modules or tasks that can be formulated as directed acyclic graph (DAG) problems. The DAG
Yuyi Jiang, Zhiqing Shao, Yi Guo
doaj +1 more source
Distributed mining of molecular fragments [PDF]
In real world applications sequential algorithms of data mining and data exploration are often unsuitable for datasets with enormous size, high-dimensionality and complex data structure.
Berthold, Michael R., Di Fatta, Giuseppe
core
Molecular computers for molecular robots as hybrid systems
Theoretical Computer Science, 2016 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Masami Hagiya +3 more
openaire +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source