Results 71 to 80 of about 224,084 (299)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Automating fault tolerance in high-performance computational biological jobs using multi-agent approaches [PDF]

, 2014
Background: Large-scale biological jobs on high-performance computing systems require manual intervention if one or more computing cores on which they execute fail.
Varghese, Blesson, McKee, Gerard, Alexandrov, Vassil   +2 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

MoMA-LigPath: A web server to simulate protein-ligand unbinding [PDF]

, 2013
Protein-ligand interactions taking place far away from the active site, during ligand binding or release, may determine molecular specificity and activity. However, obtaining information about these interactions with experimental or computational methods
Al Bluwi, Ibrahim, Devaurs, Didier, Vaisset, Marc, Iehl, Romain, Bouard, Léa, Al-Bluwi, Ibrahim, Siméon, Thierry, Cortés, Juan, Zanon, Christophe   +8 more
core   +1 more source

Fragment molecular orbital-based variational quantum eigensolver for quantum chemistry in the age of quantum computing

Scientific Reports
Quantum computers offer significant potential for complex system analysis, yet their application in large systems is hindered by limitations such as qubit availability and quantum hardware noise.
Hocheol Lim, Doo Hyung Kang, Jeonghoon Kim, Aidan Pellow-Jarman, Shane McFarthing, Rowan Pellow-Jarman, Hyeon-Nae Jeon, Byungdu Oh, June-Koo Kevin Rhee, Kyoung Tai No   +9 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

MIComp: 3D on-chip magneto-inductive computing with simultaneous wireless information and power transfer [PDF]

, 2018
On-chip computing platforms have bottlenecks including cost and physical limits of scaling transistors, communication bottleneck, energy efficiency and speed costs for memory.
Gorkem Memisoglu, Burhan Gulbahar, Gülbahar, Burhan, Memişoğlu, G.   +3 more
core   +1 more source

Algorithm Design for Multicellular Molecular Communication Simulations

Engineering Proceedings
Computing interactions among cells is computationally complex in multicellular molecular communication simulations, making the design of efficient algorithms crucial. We review simulation algorithms for computing interactions among cells in multicellular
Shohei Imanaka, Tadashi Nakano
doaj   +1 more source

Probe computing model based on small molecular switch

BMC Bioinformatics, 2019
Background DNA is a promising candidate for the construction of biological devices due to its unique properties, including structural simplicity, convenient synthesis, high flexibility, and predictable behavior.
Yanan Wang, Qi Lv, Yingying Zhang, Luhui Wang, Yafei Dong   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source