Results 61 to 70 of about 224,084 (299)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Molecular dynamics simulations of complex systems including HIV-1 protease [PDF]
, 2010 Advances in supercomputer architectures have resulted in a situation where many scienti fic codes are used on systems whose performance characteristics di ffer considerably from the platform they were developed and optimised for.
Kenway, O.A., Kenway, OA
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
DNA as a vehicle for the self-assembly model of computing [PDF]
, 1998 A DNA version of the self-assembly model of computing, feasible using currently available laboratory techniques, is proposed. Input signals are coded into unmethylated and methylated oligonucleotides which then hybridize with a backbone that contains ...
Conrad, M., Zauner, K.-P.
core
BMC Bioinformatics, 2022 Background Accurate cancer classification is essential for correct treatment selection and better prognostication. microRNAs (miRNAs) are small RNA molecules that negatively regulate gene expression, and their dyresgulation is a common disease mechanism ...
Emily Kaczmarek +6 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Can Molecular Quantum Computing Bridge Quantum Biology and Cognitive Science?
Intelligent ComputingRecently, quantum biology and molecular quantum computation have attracted substantial attention. Quantum biology applies quantum mechanics to biological systems at the molecular scale.
Wei Wu +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular Computing with Artificial Neurons [PDF]
, 2000 Today's computers are built up from a minimal set of standard pattern recognition operations. Logic gates, such as NAND, are common examples. Biomolecular materials offer an alternative approach, both in terms of variety and context sensitivity. Enzymes,
Conrad, M., Zauner, K.-P.
core
On the Design of Molecular Excitonic Circuits for Quantum Computing: The Universal Quantum Gates [PDF]
, 2019 This manuscript presents a theoretical strategy for encoding elementary quantum computing operations into the design of molecular excitonic circuits. Specifically, we show how the action of a unitary transformation of coupled two-level systems can be ...
Amro, Dodin +2 more
core +1 more source