Results 121 to 130 of about 770,458 (344)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Crystal structures of N,N-dimethyl-(2-(2,2-diphenyl)-2-prop-2-ynyloxy)acetoxy)ethylamine and N,N-dimethyl-(2-(2,2-diphenyl)-2-prop-2-ynyloxy)acetoxy)ethylammonium 2,4,6-trinitrophenolate

Acta Crystallographica Section E: Crystallographic Communications, 2017
The N,N-dimethylethylamminium unit in N,N-dimethyl-[2-(2,2-diphenyl)-2-prop-2-ynyloxyacetoxy]ethylamine, C21H23NO3 (I), is disordered over two sets of atomic sites having occupancies of 0.880 (3) and 0.
Mohammed A. E. Shaibah, Hemmige S. Yathirajan, S. Madan Kumar, Kullaiah Byrappa, Christopher Glidewell   +4 more
doaj   +1 more source

Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. [PDF]

, 2019
We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to obtain a comprehensive view of transporter dynamics (85.8% sequence coverage) occurring throughout the multidrug efflux transporter P-glycoprotein (P-gp) in three distinct conformational ...
Chang, Geoffrey, Komives, Elizabeth A, Kopcho, Noah   +2 more
core   +1 more source

On the conformational state of molecules in molecularly thin shearing films [PDF]

, 2015
Jacob N. Israelachvili, Carlos Drummond
openalex   +1 more source

Molecular dynamics simulations reveal the impact of NUTD15 variants in structural conformation and dynamics [PDF]

, 2022
Elena Gómez-Rubio, Javier García‐Marín   +1 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Unveiling the Influence of Linkers on Conformations of Oligomeric Acceptors for High‐Performance Polymer Solar Cells

Advanced Science
Conformational isomerism of organic photovoltaic materials has a profound impact on their molecular packing and therefore performance of polymer solar cells (PSCs).
Jingnan Wu, Fengbo Sun, Xunchang Wang, Qiaonan Chen, Leandro R. Franco, Xufan Zheng, C. Moyses Araujo, Renqiang Yang, Donghong Yu, Ergang Wang   +9 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Charge transport in a zinc–porphyrin single-molecule junction

Beilstein Journal of Nanotechnology, 2011
We have investigated charge transport in ZnTPPdT–Pyr (TPPdT: 5,15-di(p-thiolphenyl)-10,20-di(p-tolyl)porphyrin) molecular junctions using the lithographic mechanically controllable break-junction (MCBJ) technique at room temperature and cryogenic ...
Mickael L. Perrin, Christian A. Martin, Ferry Prins, Ahson J. Shaikh, Rienk Eelkema, Jan H. van Esch, Jan M. van Ruitenbeek, Herre S. J. van der Zant, Diana Dulić   +8 more
doaj   +1 more source

Conformational Switching of Human G-Quadruplexed DNA with Ligand Binding under Molecular Crowding Conditions [PDF]

, 2013
Yasemin Kopkalli, A. Hope, Lesley Davenport   +2 more
openalex   +1 more source