Results 131 to 140 of about 496,088 (311)
, 2013 This paper describes the occurrence of two crystalline solvate forms of the nitrosyl ruthenium complex fac-[RuCl3(NO)(dppb)] (dppb = 1,4-bis(diphenylphosphino)butane), and the role of acetone and chloroform inclusions on molecular conformations and ...
Ellena, Javier +4 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Synthesis and Conformation of 2-Aminophenyldiarylperfluoroalkylmethanes (Molecular Propellers)
, 2016 Synthesis and Conformation of 2-Aminophenyldiarylperfluoroalkylmethanes (Molecular ...
Donald Van Derveer (3026268) +4 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Chemoinformatics approaches for new drugs discovery [PDF]
, 2013 Chemoinformatics uses computational methods and technologies to solve chemical problems. It works on molecular structures, their representations, properties and related data.
Fanton, Marco
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular conformation of polyelectrolytes inside Layer-by-Layer assembled films. [PDF]
Nat Commun, 2023 Gutfreund P +5 more
europepmc +1 more source
Identifizierung von Haplotypen bei Pityogenes chalcographus (Col., Scolytidae) durch SSCP
, 2008 Pityogenes chalcographus is a widely distributed spruce pest in Eurasia (KNIZEK et al. 2005). In 70ies, E. Führer studied the intraspecific variation of this spruce bark beetle and detected race differentiation among European populations based on ...
Stauffer, Christian +2 more
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