Results 141 to 150 of about 3,978,643 (305)

Conformative Coupling of Two Conformational Molecular Switches

Angewandte Chemie International Edition, 2003
Karle, M, Bockelmann, D, Schumann, Dirk, Griesinger, Christian, Koert, U.   +4 more
openaire   +4 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Molecular dynamics of conformation-specific dopamine transporter-inhibitor complexes

, 2017
The recreational psychostimulant cocaine inhibits dopamine reuptake from the synapse, resulting in excessive stimulation of postsynaptic dopamine receptors in brain areas associated with reward and addiction. Cocaine binds to and stabilizes the outward- (
Surratt, Christopher K., Bernandie Jean, Christopher K. Surratt, Jeffry D. Madura, Madura, Jeffry D., Jean, Bernandie   +5 more
core   +1 more source

On the Role of Molecular Conformation of the 8-Oxoguanine Lesion in Damaged DNA Processing by Polymerases. [PDF]

J Chem Inf Model, 2023
Geronimo I, Vidossich P, De Vivo M.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Combinatorial Screening of Cationic Lipidoids Reveals How Molecular Conformation Affects Membrane-Targeting Antimicrobial Activity. [PDF]

ACS Appl Mater Interfaces, 2023
Jennings J, Ašćerić D, Semeraro EF, Lohner K, Malanovic N, Pabst G.   +5 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The structure and conformation of 3-methylphosphacymantrene

, 1984
Restricted Access.The proton NMR spectrum of 3-methylphosphacymantrene in a nematic solvent has been interpreted in terms of the molecular structure and conformation.
C.L. Khetrapal, A.C. Kunwar, Khetrapal, C.L., Suryaprakash, N., Kunwar, A.C., N. Suryaprakash   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A quadratic assignment formulation of the molecular conformation problem

, 1994
The molecular conformation problem is discussed, and a concave quadratic global minimization approach for solving it is described. This approach is based on a quadratic assignment formulation of a discrete approximation to the original ...
A. T. Phillips, J. B. Rosen
core