Results 141 to 150 of about 456,192 (265)

Monitoring the Molecular Conformation of Individual Amphotericin B Molecules in an Aggregated State by Raman Optical Activity. [PDF]

Anal Chem
Pajor K, Zając G, Fusè M, Mach-Liszka M, Arczewska M, Gagoś M, Onaka Y, Fujisawa T, Unno M, Baranska M, Machalska E.   +10 more
europepmc   +1 more source

Exploring the Molecular Conformation Space by Soft Molecule-Surface Collision. [PDF]

J Am Chem Soc, 2020
Anggara K, Zhu Y, Delbianco M, Rauschenbach S, Abb S, Seeberger PH, Kern K.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Electrically modulated photothermal force microscopy for revealing molecular conformation changes during polarization switching at the nanoscale. [PDF]

Nat Commun
Yao S, Jiang H, Wen J, Shu D, Xu C, Zhu W, Zhang X, Zheng Y.   +7 more
europepmc   +1 more source

Effect of intramolecular hydrogen-bond formation on the molecular conformation of amino acids. [PDF]

Commun Chem, 2020
Giubertoni G, Sofronov OO, Bakker HJ.
europepmc   +1 more source

True molecular conformation and structure determination by three-dimensional electron diffraction of PAH by-products potentially useful for electronic applications. [PDF]

IUCrJ, 2023
Andrusenko I, Hall CL, Mugnaioli E, Potticary J, Hall SR, Schmidt W, Gao S, Zhao K, Marom N, Gemmi M.   +9 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Tuning Excited-State Properties in Pyrrolo[3,2-<i>b</i>]pyrrole-Based Donor-Acceptor Emitters via Molecular Conformation and Conjugation Control. [PDF]

Molecules
Gan T, Su J, Li F, Li Q, Shi C.
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Insight into the stabilization mechanism of rice protein amyloid fibrils modification on soy protein isolate gels: Gel properties, microstructure, and molecular conformation. [PDF]

Food Chem X
Ma J, Wang L, Pan D, Wang K, Huo J, Ma X, Lu B, Yu X, Xiao Z.   +8 more
europepmc   +1 more source