Results 211 to 220 of about 4,904,917 (369)

Molecular mechanism of in vitro 30 S ribosome assembly. I. Conformational changes of the 16 S RNA.

, 1979
John M. Dunn, K.P. Wong
openalex   +1 more source

Tau induces formation of α-synuclein filaments with distinct molecular conformations

, 2021
Alimohammad Hojjatian, Anvesh K. R. Dasari, Urmi Sengupta, Dianne W. Taylor, Nadia Daneshparvar, Fatemeh Abbasi Yeganeh, Lucas Dillard, Brian Michael, Robert G. Griffin, Mario J. Borgnia, Rakez Kayed, Kenneth A. Taylor, Kwang Hun Lim   +12 more
openalex   +2 more sources

Predicting New Protein Conformations from Molecular Dynamics Simulation Conformational Landscapes and Machine Learning [PDF]

, 2020
Yiming Jin, Linus O. Johannissen, Sam Hay   +2 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Electrically modulated photothermal force microscopy for revealing molecular conformation changes during polarization switching at the nanoscale. [PDF]

Nat Commun
Yao S, Jiang H, Wen J, Shu D, Xu C, Zhu W, Zhang X, Zheng Y.   +7 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Monitoring the Molecular Conformation of Individual Amphotericin B Molecules in an Aggregated State by Raman Optical Activity. [PDF]

Anal Chem
Pajor K, Zając G, Fusè M, Mach-Liszka M, Arczewska M, Gagoś M, Onaka Y, Fujisawa T, Unno M, Baranska M, Machalska E.   +10 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combined experimental powder X-ray diffraction and DFT data to obtain the lowest energy molecular conformation of friedelin [PDF]

, 2012
Djalma Menezes de Oliveira, Wagner da Nova Mussel, Lucienir Pains Duarte, Grácia Divina de Fátima Silva, Hélio A. Duarte, Elionai Cassiana de Lima Gomes, Luciana Guimarães, Sidney Augusto Vieira Filho   +7 more
openalex   +1 more source

Tuning Excited-State Properties in Pyrrolo[3,2-<i>b</i>]pyrrole-Based Donor-Acceptor Emitters via Molecular Conformation and Conjugation Control. [PDF]

Molecules
Gan T, Su J, Li F, Li Q, Shi C.
europepmc   +1 more source