Results 71 to 80 of about 1,982,601 (316)

PD-L1 siRNA hitched polyethyleneimine-elastase constituting nanovesicle induces tumor immunogenicity and PD-L1 silencing for synergistic antitumor immunotherapy

Journal of Nanobiotechnology
Background PD-1/PD-L1 blockade has become a powerful method to treat malignant tumors. However, a large proportion of patients still do not benefit from this treatment, due to low tumor immunogenicity and low tumor penetration of the agents.
Li Du, Yao Gong, Xiaoying Zhang, Jide Sun, Fengxia Gao, Meiying Shen, Huili Bai, Tiantian Yang, Xiaoxue Cheng, Siqiao Li, Jian Peng, Zhangling Liu, Shijia Ding, Junman Chen, Wei Cheng   +14 more
doaj   +1 more source

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source

Ectomycorrhizal fungi - Molecular tools to study species and functional diversity [PDF]

, 2003
The extramatrical mycelium of ectomycorrhizal (EM) fungi represents a significant component of the ectomycorrhizal (EM) symbiosis, as the mycelium is primarily involved in the uptake of water and nutrients from the soil.
Landeweert, R.
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Optimised padlock probe ligation and microarray detection of multiple (non-authorised) GMOs in a single reaction [PDF]

, 2008
Background To maintain EU GMO regulations, producers of new GM crop varieties need to supply an event-specific method for the new variety. As a result methods are nowadays available for EU-authorised genetically modified organisms (GMOs), but only to a ...
Aarts, H.J.M., AM Angeline Van Hoef, van Dijk, J.P., van Hoef, A.M.A., Kok, E.J., Esther J Kok, Henriek G Beenen, Schoen, C.D., Beenen, H.G., Cor D Schoen, Henk JM Aarts, Marleen M Voorhuijzen, Hoef, A.M.A., van, Jeroen P van Dijk, Theo W Prins, Dijk, J.P., van, Prins, T.W., Voorhuijzen, M.M.   +17 more
core   +1 more source

Single-cell DNA methylation analysis tool Amethyst resolves distinct non-CG methylation patterns in human astrocytes and oligodendrocytes

Communications Biology
Single-cell sequencing technologies have revolutionized biomedical research by enabling deconvolution of cell type-specific properties from heterogeneous tissue.
Lauren E. Rylaarsdam, Benjamin W. Skubi, Ruth V. Nichols, Brendan L. O’Connell, Jack Henry Kotnik, Stephen D. Coleman, Galip Gürkan Yardımcı, Andrew C. Adey   +7 more
doaj   +1 more source

Shox2 and Rassf1a DNA methylation: diagnostic utility and association with clinical stage, histological progression and gene mutational landscape in lung adenocarcinoma

Frontiers in Oncology
BackgroundLung cancer, characterized by its high global incidence and mortality rates, necessitates comprehensive and precise stratification strategies to guide the diverse diagnostic approaches and therapeutic agents in clinical decision-making ...
Yixin Li, Yangli Zhang, Abida Alimu, Yulu Tan, Xiaojie Zhang, Linguo Xiang, Jia Li, Zhangling Liu, Zhangling Liu   +8 more
doaj   +1 more source

Detection and Molecular Characterization of a Canine Norovirus

Emerging Infectious Diseases, 2008
We identified a novel calicivirus in a pup with enteritis. The isolate was related genetically (90.1% aa identity in the capsid protein) to a lion norovirus strain.
Martella V, Lorusso E, Decaro N, Elia G, Radogna A, D'Abramo M, Desario C, Cavalli A, Corrente M, Camero M, Germinario CA, Bányai K, DI MARTINO, Barbara, MARSILIO, Fulvio, Carmichael LE, Buonavoglia C.   +15 more
openaire   +5 more sources

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Development of sensors for the detection of clinically relevant substances using molecular imprinting [PDF]

, 2009
This thesis investigates the development of sensing devices based on molecularly imprinted polymers for the detection of clinically relevant analytes. Three analytes were considered, metronidazole, creatinine and propofol.
Fowler, Steven A.
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