Results 51 to 60 of about 977,473 (267)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Genetic analyses identify circulating genes related to brain structures associated with Parkinson’s disease

npj Parkinson's Disease
Magnetic resonance imaging and circulating molecular testing are potential methods for diagnosing and treating Parkinson’s disease (PD). However, their relationships remain insufficiently studied.
Zhe Han, Yanping Zhu, Zhenhong Xia, Qing Deng, Hongjie He, Quanting Yin, Hui Zhang, Mudan Yuan, Chunhua Yang, Geng Tian, Jia Mi, Fuyi Xu   +11 more
doaj   +1 more source

Clinical and molecular characteristics, antibiotic susceptibility, risk factors and predictors of mortality in carbapenem-resistant klebsiella pneumoniae bloodstream infections in Southern Sichuan, China: a 5-year multicenter study

Frontiers in Cellular and Infection Microbiology
BackgroundThe World Health Organization (WHO) has listed carbapenem-resistant Klebsiella pneumoniae (CRKP) as one of the key pathogens that require the highest priority for containment.
Wenchao Xie, Wenchao Xie, Wenchao Xie, Zixiang Luo, Zixiang Luo, Zixiang Luo, Chenghong Gu, yanzhi Li, yanzhi Li, yanzhi Li, Jie Deng, Jie Deng, Jie Deng, Yuling Yang, Yueshuai Wei, Yueshuai Wei, Yueshuai Wei, Yuan Jiang, Yuan Jiang, Yuan Jiang, Jinbo Liu, Jinbo Liu, Jinbo Liu, Zhangrui Zeng, Zhangrui Zeng, Zhangrui Zeng   +25 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Development of a Recombinant Outer Membrane Vesicles (OMVs)‐Based Vaccine Against Helicobacter pylori Infection in Mice

Journal of Extracellular Vesicles
The current vaccine development for Helicobacter pylori (H. pylori) still faces challenges of weak immune responses stimulated by existing antigens and a lack of safe adjuvants. The modification of the lipopolysaccharide (LPS) structure by H.
Qiong Liu, Biaoxian Li, Jinrong Ma, Xiao Lei, Junpeng Ma, Yanyan Da, Zhiyong Zhou, Jiaqi Tao, Xinyi Ren, Ting Zeng, Zhiting Xie, Haiyan Lin, Zihui Jin, Yi Wan, Liang Zhang, Donglin Lai, Yaping Guo, Jing Li, Yinpan Shang, Lu Shen, Ziwei Tao, Tian Gong, Chengsheng Zhang   +22 more
doaj   +1 more source

Utility of four machine learning approaches for identifying ulcerative colitis and Crohn's disease

Heliyon
Objective: Peripheral blood routine parameters (PBRPs) are simple and easily acquired markers to identify ulcerative colitis (UC) and Crohn's disease (CD) and reveal the severity, whereas the diagnostic performance of individual PBRP is limited.
Jingwen Pei, Guobing Wang, Yi Li, Lan Li, Chang Li, Yu Wu, Jinbo Liu, Gang Tian   +7 more
doaj   +1 more source

Can Statin Treatment Reduce the Risk of Hepatocellular Carcinoma? A Systematic Review and Meta-Analysis

Technology in Cancer Research & Treatment, 2020
Background: Whether statins can reduce the incidence of cancers has been an interesting topic in recent years. This meta-analysis aimed to determine the relationship between statin treatment with the risk of hepatocellular carcinoma.
Yue Chang MM, Qinyu Liu MM, Zidong Zhou MM, Yuping Ding MD, Mei Yang MM, Wei Xu MD, Kai Chen MM, Qing Zhang MM, Zhenguo Wang MM, Hai Li MD   +9 more
doaj   +1 more source

Molecular diagnosis of phytoplasmas.

Phytopathologia Mediterranea, 2003
Phytoplasmas are wall-less prokaryotes associated with diseases in numerous plant species worldwide. In nature they are transmitted by phloem-sucking insects. Yellowing, decline, witches’ broom, leaf curl, floral virescence and phyllody are the most conspicuous symptoms associated with phytoplasmas, although infections are sometimes asymptomatic. Since
openaire   +5 more sources