Results 51 to 60 of about 632,987 (205)

The impact of molecular biology on assessment of water quality: advantages and limitations of current techniques [PDF]

, 1997
The advent of molecular biology has had a dramatic impact on all aspects of biology, not least applied microbial ecology. Microbiological testing of water has traditionally depended largely on culture techniques.
Saunders, J.R., Saunders, V.A.
core  

A decade of whole-exome sequencing in Brazilian Neurology: from past insights to future perspectives

Arquivos de Neuro-Psiquiatria
Over the last decade, whole-exome sequencing (WES) has become a standard diagnostic tool, significantly transforming the landscape of clinical genetics and playing a pivotal role in the diagnosis of neurogenetic diseases.
Caio Robledo D'Angioli Costa Quaio, Thiago Yoshinaga Tonholo Silva, Orlando G. Barsottini, Sarah Teixeira Camargos, Marcondes C. França, Jonas A. Saute, Wilson Marques, Fernando Kok, José Luiz Pedroso   +8 more
doaj   +1 more source

Multiplex ligation-dependent probe amplification (MLPA) analysis is an effective tool for the detection of novel intragenic PLA2G6 mutations: Implications for molecular diagnosis [PDF]

, 2010
Phospholipase associated neurodegeneration (PLAN) comprises a heterogeneous group of autosomal recessive neurological disorders caused by mutations in the PLA2G6 gene. Direct gene sequencing detects 85% mutations in infantile neuroaxonal dystrophy.
Brady, Angela F, Crompton, Danielle, De Gressi, Susanna, Foster, Kathleen, Hardy, Carol, Hughes, Imelda, Kurian, Manju A, Lunt, Peter, MacPherson, Lesley, Maher, Eamonn R, McDonald, Fiona, Morgan, Neil V, Pike, Michael G, Rehal, Pauline K, Smith, Matthew   +14 more
core   +1 more source

Molecular techniques for cancer diagnostics

Academia Medicine
Cancer cells differ from healthy tissues in their biological makeup. Recent research reported vast genetic and epigenetic heterogeneity, differences in the gene-expression profiles, and signal transduction networks in a broad range of cancers. These discoveries led to the development and clinical approval of several drugs that are more efficient and ...
Vimal Kishor Singh, Ramesh Chandra
openaire   +2 more sources

The cervical transcriptome changes during the menstrual cycle but does not predict the window of implantation

Frontiers in Reproductive Health, 2023
IntroductionThe expression of genes in female reproductive organs is influenced by the cyclic changes in hormone levels during the menstrual cycle. While the molecular changes in the endometrium that facilitate embryo implantation have been extensively ...
Amruta D. S. Pathare, Merli Saare, Merli Saare, Alvin Meltsov, Alvin Meltsov, Ankita Lawarde, Ankita Lawarde, Vijayachitra Modhukur, Vijayachitra Modhukur, Aive Kalinina, Aire Sekavin, Viktorija Kukushkina, Helle Karro, Helle Karro, Andres Salumets, Andres Salumets, Andres Salumets, Andres Salumets, Maire Peters, Maire Peters   +19 more
doaj   +1 more source

Salivary Biomarkers for Oral Squamous Cell Carcinoma Diagnosis and Follow-Up: Current Status and Perspectives [PDF]

, 2019
Oral cancer is the sixth most common cancer type in the world, and 90% of it is represented by oral squamous cell carcinoma (OSCC). Despite progress in preventive and therapeutic strategies, delay in OSCC diagnosis remains one of the major causes of high
Campisi, Giuseppina, Cristaldi, Marta, Di Fede, Olga, Giuliana, Giovanna, Mauceri, Rodolfo, Panzarella, Vera   +5 more
core   +1 more source

Molecular techniques for clinical diagnostic bacteriology

Turkish Bulletin of Hygiene and Experimental Biology, 2015
Moleküler yöntemler enfeksiyon hastalıkların patogenezinin ve epidemiyolojisinin anlaşılmasında çok önemli katkıda bulunmuştur. Polimeraz zincir reaksiyonu (PZR), en yaygın kullanılan hedef nükleik asit amplifikasyon yöntemidir. Bu yöntem ile tek bir nükleik asidin kopyası çok kısa bir süre içinde 107 kereden fazla çoğalır.
openaire   +3 more sources

Vaccination With a Gamma Irradiation-Inactivated African Swine Fever Virus Is Safe But Does Not Protect Against a Challenge

Frontiers in Immunology, 2022
African swine fever (ASF) is among the most devastating viral diseases of pigs and wild boar worldwide. In recent years, the disease has spread alarmingly.
Jutta Pikalo, Luca Porfiri, Valerij Akimkin, Hanna Roszyk, Katrin Pannhorst, Richard Thiga Kangethe, Viskam Wijewardana, Julia Sehl-Ewert, Martin Beer, Giovanni Cattoli, Sandra Blome   +10 more
doaj   +1 more source

Non-Empirically Tuned Range-Separated DFT Accurately Predicts Both Fundamental and Excitation Gaps in DNA and RNA Nucleobases [PDF]

, 2012
Using a non-empirically tuned range-separated DFT approach, we study both the quasiparticle properties (HOMO-LUMO fundamental gaps) and excitation energies of DNA and RNA nucleobases (adenine, thymine, cytosine, guanine, and uracil).
Foster, Michael E., Wong, Bryan M.
core   +2 more sources

From phenotypic to molecular diagnosis: Insights from a clinical immunology service focused on inborn errors of immunity in Colombia

Biomédica: revista del Instituto Nacional de Salud
Introduction. Inborn errors of immunity include a broad spectrum of genetic diseases, in which a specific gene mutation might alter the entire emphasis and approach for an individual patient. Objective.
Mónica Fernandes Pineda, Andrés F. Zea-Vera   +1 more
doaj   +1 more source