Results 71 to 80 of about 680,341 (256)

Plasma-based longitudinal mutation monitoring as a potential predictor of disease progression in subjects with adenocarcinoma in advanced non-small cell lung cancer

BMC Cancer, 2020
Background Identifying and tracking somatic mutations in cell-free DNA (cfDNA) by next-generation sequencing (NGS) has the potential to transform the clinical management of subjects with advanced non-small cell lung cancer (NSCLC). Methods Baseline tumor
John Jiang, Hans-Peter Adams, Maria Lange, Sandra Siemann, Mirjam Feldkamp, Sylvie McNamara, Sebastian Froehler, Stephanie J. Yaung, Lijing Yao, Aarthi Balasubramanyam, Nalin Tikoo, Christine Ju, H. Jost Achenbach, Rainer Krügel, John F. Palma   +14 more
doaj   +1 more source

The role of metabolomics in hepatocellular carcinomas

Egyptian Liver Journal, 2021
Background Hepatocellular carcinoma is the most common primary liver malignancy, with the highest incidence in the developing world, including Egypt. Hepatocellular carcinoma is usually diagnosed in the terminal stage of the disease because of the low ...
Ashraf Khalil, Ashraf Elfert, Samar Ghanem, Marwa Helal, Shymaa Abdelsattar, Gamalate Elgedawy, Manar Obada, Mohammed Abdel Abdel-Samiee, Hala El-Said   +8 more
doaj   +1 more source

A metastatic secretory gastric plasmacytoma with aberrant CD3 expression in a dog [PDF]

, 2017
A 10-year-old crossbred dog was presented with a 6-week history of hematemesis, melena, anorexia, and lethargy. Clinical evaluation revealed a gastric mass with a regional lymphadenomegaly as well as a monoclonal gammopathy manifesting as ...
Atherton, Matthew J., Morris, Joanna S., Sharpe, Sam, Vazquez-Sanmartin, Samantha, Waugh, Elspeth M.   +4 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

A novel approach for rapid high-throughput selection of recombinant functional rat monoclonal antibodies

BMC Immunology, 2018
Background Most monoclonal antibodies against mouse antigens have been derived from rat spleen-mouse myeloma fusions, which are valuable tools for purposes ranging from general laboratory reagents to therapeutic drugs, and yet selecting and expressing ...
Qin Chen, Shengping Qiu, Huanhuan Li, Chaolong Lin, Yong Luo, Wenfeng Ren, Yidi Zou, Yale Wang, Ninghshao Xia, Chenghao Huang   +9 more
doaj   +1 more source

Association of long-term exposure to PM2.5 with hypertension and diabetes among the middle-aged and elderly people in Chinese mainland: a spatial study

BMC Public Health, 2022
Background Epidemiological evidence has shown an association between long-term exposure to fine particulate matter (PM2.5) and hypertension and diabetes, but few studies have considered the spatial properties of the samples.
Zirong Ye, Xueru Li, Yaofeng Han, Yafei Wu, Ya Fang   +4 more
doaj   +1 more source

Perspektiven der molekularen Diagnostik für public health und die Gesundheitswirtschaft: Eine Literaturstudie [PDF]

, 2007
Als Molekulare Diagnostik werden alle diagnostischen Methoden verstanden, die auf der Grundlage molekularer oder biochemischer Analysen in vivo (im lebenden Organismus) und in vitro (im Versuch, außerhalb des Organismus) gemacht werden.
Henke, Klaus-Dirk, Martin, Karl
core  

Clustering, conductor-insulator transition and phase separation of an ultrasoft model of electrolytes

, 2011
We investigate the clustering and phase separation of a model of ultrasoft, oppositely charged macroions by a combination of Monte Carlo and Molecular Dynamics simulations.
Coslovich, Daniele, Hansen, Jean-Pierre, Kahl, Gerhard   +2 more
core   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source