Results 141 to 150 of about 711,460 (319)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The molecular evolution of vertebrate organs. [PDF]
Nat Ecol EvolCardoso-Moreira M.
europepmc +1 more source
Molecular Modeling in Enzyme Design, Toward In Silico Guided Directed Evolution
, 2017 Emanuele Monza +3 more
openalex +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The molecular determinants and consequences of recombination in the evolution of human enteroviruses [PDF]
, 2011 Kym Lowry
openalex
H i Narrow Self‐Absorption in Dark Clouds: Correlations with Molecular Gas and Implications for Cloud Evolution and Star Formation [PDF]
, 2005 P. F. Goldsmith, Di Li
openalex +1 more source
Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss
, 2021 Najmeh Parvaz, Zahra Jalali
openalex +2 more sources