Results 21 to 30 of about 9,026,651 (342)
Linking molecular evolution to molecular grafting [PDF]
Journal of Biological Chemistry, 2021 Molecular grafting is a strategy for the engineering of molecular scaffolds into new functional agents, such as next-generation therapeutics. Despite its wide use, studies so far have focused almost exclusively on demonstrating its utility rather than understanding the factors that lead to either poor or successful grafting outcomes.
Conan K. Wang, David J. Craik
openaire +2 more sources
Molecular Evolution in Collapsing Prestellar Cores [PDF]
, 2001 We have investigated the evolution and distribution of molecules in collapsing prestellar cores via numerical chemical models, adopting the Larson-Penston solution and its delayed analogues to study collapse.
Brown P. D. +15 more
core +4 more sources
Selective pressures on genomes in molecular evolution [PDF]
, 2003 We describe the evolution of macromolecules as an information transmission process and apply tools from Shannon information theory to it. This allows us to isolate three independent, competing selective pressures that we term compression, transmission ...
Adami +34 more
core +2 more sources
Molecular Evolution of Aphthoviruses
Virus Genes, 1995 Aphthoviruses are an important group of animal pathogens. A combination of genetic and structural studies has revealed one of the main principles governing their evolution: severe limitations to variation imposed by functional and structural constraints, in conjunction with high mutation and recombination rates operating during genome replication ...
Domingo, Esteban +7 more
openaire +3 more sources
W(h)ither Fossils? Studying Morphological Character Evolution in the Age of Molecular Sequences [PDF]
, 2008 A major challenge in the post-genomics era will be to integrate molecular sequence data from extant organisms with morphological data from fossil and extant taxa into a single, coherent picture of phylogenetic relationships; only then will these ...
Bull J. J. +21 more
core +2 more sources
Molecular Evolution of the Major Arthropod Chemoreceptor Gene Families.
Annual Review of Entomology, 2019 The evolutionary origins of the three major families of chemoreceptors in arthropods-the odorant receptor (OR), gustatory receptor (GR), and ionotropic receptor (IR) families-occurred at the base of the Insecta, Animalia, and Protostomia, respectively ...
H. Robertson
semanticscholar +1 more source
Rate variation during molecular evolution: creationism and the cytochrome c molecular clock [PDF]
, 2017 Molecular clocks based upon amino acid sequences in proteins have played a major role in the clarification of evolutionary phylogenies. Creationist criticisms of these methods sometimes rely upon data that might initially seem to be paradoxical.
Hofmann James, R.
core +1 more source
A Hierarchical Approach to Protein Molecular Evolution [PDF]
, 1999 Biological diversity has evolved despite the essentially infinite complexity of protein sequence space. We present a hierarchical approach to the efficient searching of this space and quantify the evolutionary potential of our approach with Monte Carlo ...
Crameri +30 more
core +2 more sources
Plastid origin: who, when and why?
Acta Societatis Botanicorum Poloniae, 2014 The origin of plastids is best explained by endosymbiotic theory, which dates back to the early 1900s. Three lines of evidence based on protein import machineries and molecular phylogenies of eukaryote (host) and cyanobacterial (endosymbiont) genes point
Chuan Ku +5 more
doaj +1 more source
The Jackprot Simulation Couples Mutation Rate with Natural Selection to Illustrate How Protein Evolution Is Not Random [PDF]
, 2011 Protein evolution is not a random process. Views which attribute randomness to molecular change, deleterious nature to single-gene mutations, insufficient geological time, or population size for molecular improvements to occur, or invoke “design ...
Bai, Chunyan Y. +2 more
core +2 more sources