Results 81 to 90 of about 9,026,651 (342)

Adaptive evolution of molecular phenotypes

, 2014
Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a quantitative trait under
Armita Nourmohammad, Chernyak V Y, Crow J F, Falconer D S, Fisher R, Lynch M, Lynch M, Lynch M, Michael Lässig, Muller H J, Neher R A, Nourmohammad A, Nourmohammad A, Torsten Held   +13 more
core   +1 more source

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

Nature, 2012
Colorectal tumours that are wild type for KRAS are often sensitive to EGFR blockade, but almost always develop resistance within several months of initiating therapy.
L. Diaz, R. Williams, Jian Wu, Isaac Kinde, J. Hecht, J. Berlin, Benjamin Allen, I. Bozic, Johannes G. Reiter, M. Nowak, K. Kinzler, K. Oliner, B. Vogelstein   +12 more
semanticscholar   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Imaging the Breakdown of Molecular-Frame Dynamics through Rotational Uncoupling

, 2017
We demonstrate the breakdown of molecular-frame dynamics induced by the uncoupling of molecular rotation from electronic motion in molecular Rydberg states. We observe this non-Born-Oppenheimer regime in the time domain through photoelectron imaging of a
Bucksbaum, Philip H., Natan, Adi, Zipp, Lucas J.   +2 more
core   +1 more source

Dynamical Evolution of Globular Clusters in Hierarchical Cosmology [PDF]

, 2006
We probe the evolution of globular clusters that could form in giant molecular clouds within high-redshift galaxies. Numerical simulations demonstrate that the large and dense enough gas clouds assemble naturally in current hierarchical models of galaxy ...
Forbes D. A., Forte J. C., Frenk C. S., José L. Prieto, Kissler-Patig M., Lahav O., Maccio A. V., Miyamoto M., Murali C., Murali C., Murali C., Oleg Y. Gnedin, Scalo J. M., Thomas P.   +13 more
core   +3 more sources

DAMBE7: New and Improved Tools for Data Analysis in Molecular Biology and Evolution

Molecular biology and evolution, 2018
DAMBE is a comprehensive software package for genomic and phylogenetic data analysis on Windows, Linux, and Macintosh computers. New functions include imputing missing distances and phylogeny simultaneously (paving the way to build large phage and ...
X. Xia
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Molecular Cloud Evolution III. Accretion vs. stellar feedback

, 2010
We numerically investigate the effect of feedback from the ionizing radiation heating from massive stars on the evolution of giant molecular clouds (GMCs) and their star formation efficiency (SFE).
Alan W. Watson, Ballesteros-Paredes, Brunt, Carpenter, Carroll, Caselli, Ceverino, Diaz-Miller, Dib, Elmegreen, Elmegreen, Enrique Vázquez-Semadeni, Evans, Federrath, Gazol, Gilberto C. Gómez, Hartmann, Hartmann, Heitsch, Heitsch, Hennebelle, Hennebelle, Heyer, Hillenbrand, Hillenbrand, Javier Ballesteros-Paredes, Klessen, Klessen, Klessen, Koyama, Koyama, Kravtsov, Kravtsov, Krumholz, Krumholz, Krumholz, Li, Li, Matzner, Matzner, McKee, Nakamura, Nordlund, Ostriker, Ostriker, Padoan, Padoan, Pedro Colín, Rathborne, Rosas-Guevara, Scalo, Spaans, Spezzi, Tan, Tobin, Truelove, Vázquez-Semadeni, Vázquez-Semadeni, Vázquez-Semadeni, Vázquez-Semadeni, Vázquez-Semadeni, Vázquez-Semadeni, Wada, Wada, Wang, Whitworth, Williams, Yorke   +67 more
core   +1 more source

Molecular gastronomy : basis for a new culinary movement or modern day alchemy? [PDF]

, 2010
To explore the phenomenon of molecular gastronomy by conducting empirical research focusing on renowned chefs. Design/methodology/approach - Literature review summarising past culinary innovations then focusing on the origins and evolution of molecular ...
Cousins, John, O'Gorman, Kevin D., Stierand, Marc   +2 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source