Results 11 to 20 of about 5,499,417 (372)

Molecular genetics of Dupuytren’s contracture [PDF]

EFORT Open Reviews
Dupuytren’s contracture (DC) is a fibroproliferative disorder of the palmar fascia characterised by the digits’ flexion contractures and is associated with abnormal build-up of type III collagen.
Shankar Aissvarya, King-Hwa Ling, Manohar Arumugam, Karuppiah Thilakavathy   +3 more
doaj   +2 more sources

Molecular Genetics of Retrovirus Replication [PDF]

Viruses, 2023
Despite the availability of effective anti-HIV drug therapy, according to UNAIDS estimates, 1 [...]
Judith G. Levin, Karin Musier-Forsyth, Alan Rein   +2 more
doaj   +2 more sources

Dominant-negative heterozygous mutations in AIRE confer diverse autoimmune phenotypes

iScience, 2023
Summary: Autoimmune polyendocrine syndrome type 1 (APS-1) is an autosomal recessive disease characterized by severe and childhood onset organ-specific autoimmunity caused by mutations in the autoimmune regulator (AIRE) gene.
Bergithe E. Oftedal, Kristian Assing, Safa Baris, Stephanie L. Safgren, Isik S. Johansen, Marianne Antonius Jakobsen, Dusica Babovic-Vuksanovic, Katherine Agre, Eric W. Klee, Emina Majcic, Elise M.N. Ferré, Monica M. Schmitt, Tom DiMaggio, Lindsey B. Rosen, Muhammad Obaidur Rahman, Dionisios Chrysis, Aristeidis Giannakopoulos, Maria Tallon Garcia, Luis Ignacio González-Granado, Katherine Stanley, Jessica Galant-Swafford, Pim Suwannarat, Isabelle Meyts, Michail S. Lionakis, Eystein S. Husebye   +24 more
doaj   +1 more source

Molecular Genetics and Economics [PDF]

Journal of Economic Perspectives, 2011
The costs of comprehensively genotyping human subjects have fallen to the point where major funding bodies, even in the social sciences, are beginning to incorporate genetic and biological markers into major social surveys. How, if at all, should economists use and combine molecular genetic and economic data from these surveys?
Beauchamp, Jonathan P, Cesarini, David, Johannesson, Magnus, van der Loos, Matthijs J. H. M, Koellinger, Philipp D, Groenen, Patrick J. F, Fowler, James H, Rosenquist, James, Thurik, A. Roy, Christakis, Nicholas A.   +9 more
openaire   +6 more sources

Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice

iScience, 2023
Summary: Ionizing radiation (IR) is a risk factor for acute myeloid leukemia (rAML). Murine rAMLs feature both hemizygous chromosome 2 deletions (Del2) and point mutations (R235) within the hematopoietic regulatory gene Spi1.
Natalie Brown, Rosemary Finnon, Paul Finnon, Roisin McCarron, Lourdes Cruz-Garcia, Grainne O’Brien, Eleanor Herbert, Cheryl L. Scudamore, Edouard Morel, Christophe Badie   +9 more
doaj   +1 more source

Liver sphingomyelin synthase 1 deficiency causes steatosis, steatohepatitis, fibrosis, and tumorigenesis: An effect of glucosylceramide accumulation

iScience, 2021
Summary: Glucosylceramide (GluCer) was accumulated in sphingomyelin synthase 1 (SMS1) but not SMS2 deficient mouse tissues. In current study, we studied GluCer accumulation-mediated metabolic consequences.
Zhiqiang Li, Yeun-po Chiang, Mulin He, Tilla S. Worgall, Hongwen Zhou, Xian-Cheng Jiang   +5 more
doaj   +1 more source

Sex-biased genome-editing effects of CRISPR-Cas9 across cancer cells dependent on p53 status

iScience, 2023
Summary: The CRISPR-Cas9 system has emerged as the dominant technology for gene editing and clinical applications. One major concern is its off-target effect after the introduction of exogenous CRISPR-Cas9 into cells.
Mengbiao Guo, Yuanyan Xiong
doaj   +1 more source

Interrogating cell type-specific cooperation of transcriptional regulators in 3D chromatin

iScience, 2021
Summary: Context-specific activities of transcription regulators (TRs) in the nucleus modulate spatiotemporal gene expression precisely. Using the largest ChIP-seq data and chromatin loops in the human K562 cell line, we initially interrogated TR ...
Xianfu Yi, Zhanye Zheng, Hang Xu, Yao Zhou, Dandan Huang, Jianhua Wang, Xiangling Feng, Ke Zhao, Xutong Fan, Shijie Zhang, Xiaobao Dong, Zhao Wang, Yujun Shen, Hui Cheng, Lei Shi, Mulin Jun Li   +15 more
doaj   +1 more source

Molecular genetics of auxin signaling [PDF]

, 2002
The plant hormone auxin is a simple molecule similar to tryptophan, yet it elicits a diverse array of responses and is involved in the regulation of growth and development throughout the plant life cycle.
Leyser, O
core   +1 more source

Molecular Evolutionary Genetics Analysis (MEGA) for macOS.

Molecular biology and evolution, 2020
The Molecular Evolutionary Genetics Analysis (MEGA) software enables comparative analysis of molecular sequences in phylogenetics and evolutionary medicine. Here, we introduce the macOS version of the MEGA software.
G. Stecher, K. Tamura, Sudhir Kumar
semanticscholar   +1 more source