Results 11 to 20 of about 1,566,823 (304)

Liver sphingomyelin synthase 1 deficiency causes steatosis, steatohepatitis, fibrosis, and tumorigenesis: An effect of glucosylceramide accumulation

open access: yesiScience, 2021
Summary: Glucosylceramide (GluCer) was accumulated in sphingomyelin synthase 1 (SMS1) but not SMS2 deficient mouse tissues. In current study, we studied GluCer accumulation-mediated metabolic consequences.
Zhiqiang Li   +5 more
doaj   +1 more source

Molecular Genetics and Economics [PDF]

open access: yesJournal of Economic Perspectives, 2011
The costs of comprehensively genotyping human subjects have fallen to the point where major funding bodies, even in the social sciences, are beginning to incorporate genetic and biological markers into major social surveys. How, if at all, should economists use and combine molecular genetic and economic data from these surveys?
Beauchamp, Jonathan P   +9 more
openaire   +5 more sources

Molecular Genetics of Holoprosencephaly [PDF]

open access: yesFetal and Pediatric Pathology, 2000
Holoprosencephaly (HPE) is a common developmental defect of the human forebrain and midface. Pathological studies have identified different categories of severity of the brain and craniofacial malformations observed in HPE, although the variable clinical spectrum of HPE extends in unbroken sequence from alobar HPE and cyclopia to clinically unaffected ...
L, Nanni, R L, Schelper, M T, Muenke
openaire   +2 more sources

Molecular genetics of auxin signaling [PDF]

open access: yes, 2002
The plant hormone auxin is a simple molecule similar to tryptophan, yet it elicits a diverse array of responses and is involved in the regulation of growth and development throughout the plant life cycle.
Leyser, O
core   +1 more source

Per-nucleus crossover covariation is regulated by chromosome organization

open access: yesiScience, 2022
Summary: Meiotic crossover (CO) recombination between homologous chromosomes regulates chromosome segregation and promotes genetic diversity. Human females have different CO patterns than males, and some of these features contribute to the high frequency
Cunxian Fan   +4 more
doaj   +1 more source

Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis

open access: yesiScience, 2023
Summary: Epigenetic alterations are especially important in necrotizing enterocolitis (NEC). Here, we reported that histone deacetylase 8 (HDAC8) plays a previously unknown role in modulating arginine metabolism via acetylation of histone 3 lysine 9 ...
Ting Guo   +9 more
doaj   +1 more source

Molecular genetics in aquaculture

open access: yesItalian Journal of Animal Science, 2010
Great advances in molecular genetics have deeply changed the way of doing research in aquaculture, as it has already done in other fields. The molecular revolution started in the 1980’s, thanks to the widespread use of restriction enzymes and ...
Liliana Di Stasio   +2 more
doaj   +1 more source

ROS Regulate Caspase-Dependent Cell Delamination without Apoptosis in the Drosophila Pupal Notum

open access: yesiScience, 2020
Summary: Thorax fusion occurs in the midline of the Drosophila pupal notum and involves epithelial cell delamination requiring apoptotic signaling. By genetic screening, we found that NADPH oxidases (Nox and Duox) associated with superoxide anion (O˙-2 ...
Yuya Fujisawa   +3 more
doaj   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

open access: yes, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando   +23 more
core   +1 more source

Developmental imaging genetics: challenges and promises for translational research [PDF]

open access: yes, 2006
Advances in molecular biology, neuroimaging, genetic epidemiology, and developmental psychopathology have provided a unique opportunity to explore the interplay of genes, brain, and behavior within a translational research framework.
Hariri, A.R.   +2 more
core   +1 more source

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