Results 11 to 20 of about 1,535,544 (371)
On the Reduction of Genetics to Molecular Biology [PDF]
, 1979 The applicability of Nagel\u27s concept of theory reduction, and related concepts of reduction, to the reduction of genetics to molecular biology is examined using the lactose operon in Escherichia coli as an example.
Steven O. Kimbrough
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Molecular genetics of auxin signaling [PDF]
, 2002 The plant hormone auxin is a simple molecule similar to tryptophan, yet it elicits a diverse array of responses and is involved in the regulation of growth and development throughout the plant life cycle.
Leyser, O
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Molecular Genetics of T Cell Development [PDF]
, 2005 T cell development is guided by a complex set of transcription factors that act recursively, in different combinations, at each of the developmental choice points from T-lineage specification to peripheral T cell specialization. This review describes the
Aifantis I +27 more
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The functional mutational landscape of the lacZ gene
iScience, 2023 Summary: The lacZ gene of Escherichia coli encodes β-galactosidase (β-gal), a lactose metabolism enzyme of the lactose operon. Previous chemical modification or site-directed mutagenesis experiments have identified 21 amino acids that are essential for β-
Marc A. Beal +5 more
doaj
Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution [PDF]
Trends in Genetics 2013 29(6):358-366, 2013 The premise of genetic analysis is that a causal link exists between phenotypic and allelic variation. Yet it has long been documented that mutant phenotypes are not a simple result of a single DNA lesion, but rather are due to interactions of the focal allele with other genes and the environment.
arxiv +1 more source
CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system
iScience, 2023 Summary: Cre-mediated recombination is frequently used for cell type-specific loss of function (LOF) studies. A major limitation of this system is recombination in unwanted cell types.
Dominique J. Laster +10 more
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The role of genetics in modern medicine
Байкальский медицинский журнал, 2022 The lecture examines the role of modern genetics and its significance for medicine. The goals of genetics and its structure are determined. It is shown that modern medical genetics is divided into general genetics, clinical genetics and laboratory ...
Elena Anatolyevna Tkachuk +1 more
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Developmental imaging genetics: challenges and promises for translational research [PDF]
, 2006 Advances in molecular biology, neuroimaging, genetic epidemiology, and developmental psychopathology have provided a unique opportunity to explore the interplay of genes, brain, and behavior within a translational research framework.
Hariri, A.R. +2 more
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Network location and clustering of genetic mutations determine chronicity in a stylized model of genetic diseases [PDF]
Sci Rep 12, 19906 (2022), 2022 In a highly simplified view, a disease can be seen as the phenotype emerging from the interplay of genetic predisposition and fluctuating environmental stimuli. We formalize this situation in a minimal model, where a network (representing cellular regulation) serves as an interface between an input layer (representing environment) and an output layer ...
arxiv +1 more source
The molecular basis of T cell acute lymphoblastic leukemia [PDF]
, 2012 T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando +23 more
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