Results 21 to 30 of about 53,853 (212)

Interrogating cell type-specific cooperation of transcriptional regulators in 3D chromatin

iScience, 2021
Summary: Context-specific activities of transcription regulators (TRs) in the nucleus modulate spatiotemporal gene expression precisely. Using the largest ChIP-seq data and chromatin loops in the human K562 cell line, we initially interrogated TR ...
Xianfu Yi, Zhanye Zheng, Hang Xu, Yao Zhou, Dandan Huang, Jianhua Wang, Xiangling Feng, Ke Zhao, Xutong Fan, Shijie Zhang, Xiaobao Dong, Zhao Wang, Yujun Shen, Hui Cheng, Lei Shi, Mulin Jun Li   +15 more
doaj   +1 more source

Liver sphingomyelin synthase 1 deficiency causes steatosis, steatohepatitis, fibrosis, and tumorigenesis: An effect of glucosylceramide accumulation

iScience, 2021
Summary: Glucosylceramide (GluCer) was accumulated in sphingomyelin synthase 1 (SMS1) but not SMS2 deficient mouse tissues. In current study, we studied GluCer accumulation-mediated metabolic consequences.
Zhiqiang Li, Yeun-po Chiang, Mulin He, Tilla S. Worgall, Hongwen Zhou, Xian-Cheng Jiang   +5 more
doaj   +1 more source

Per-nucleus crossover covariation is regulated by chromosome organization

iScience, 2022
Summary: Meiotic crossover (CO) recombination between homologous chromosomes regulates chromosome segregation and promotes genetic diversity. Human females have different CO patterns than males, and some of these features contribute to the high frequency
Cunxian Fan, Xiao Yang, Hui Nie, Shunxin Wang, Liangran Zhang   +4 more
doaj   +1 more source

Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis

iScience, 2023
Summary: Epigenetic alterations are especially important in necrotizing enterocolitis (NEC). Here, we reported that histone deacetylase 8 (HDAC8) plays a previously unknown role in modulating arginine metabolism via acetylation of histone 3 lysine 9 ...
Ting Guo, Shaohua Hu, Weijue Xu, Jin Zhou, Feng Chen, Tingting Gao, Wenqian Qu, Faling Chen, Zhibao Lv, Li Lu   +9 more
doaj   +1 more source

Molecular genetics in aquaculture

Italian Journal of Animal Science, 2010
Great advances in molecular genetics have deeply changed the way of doing research in aquaculture, as it has already done in other fields. The molecular revolution started in the 1980’s, thanks to the widespread use of restriction enzymes and ...
Liliana Di Stasio, Claudio Lisa, Rossella Lo Presti   +2 more
doaj   +1 more source

ROS Regulate Caspase-Dependent Cell Delamination without Apoptosis in the Drosophila Pupal Notum

iScience, 2020
Summary: Thorax fusion occurs in the midline of the Drosophila pupal notum and involves epithelial cell delamination requiring apoptotic signaling. By genetic screening, we found that NADPH oxidases (Nox and Duox) associated with superoxide anion (O˙-2 ...
Yuya Fujisawa, Natsuki Shinoda, Takahiro Chihara, Masayuki Miura   +3 more
doaj   +1 more source

Molecular Genetics in Neuroblastoma Prognosis

Children, 2021
In recent years, much research has been carried out to identify the biological and genetic characteristics of the neuroblastoma (NB) tumor in order to precisely define the prognostic subgroups for improving treatment stratification.
Margherita Lerone, Marzia Ognibene, Annalisa Pezzolo, Giuseppe Martucciello, Federico Zara, Martina Morini, Katia Mazzocco   +6 more
doaj   +1 more source

Molecular Genetics of Retrovirus Replication

Viruses, 2023
Despite the availability of effective anti-HIV drug therapy, according to UNAIDS estimates, 1 [...]
Judith G. Levin, Karin Musier-Forsyth, Alan Rein   +2 more
doaj   +1 more source

DNA methylation-based profiling of horse archaeological remains for age-at-death and castration

iScience, 2023
Summary: Age profiling of archaeological bone assemblages can inform on past animal management practices, but is limited by the fragmentary nature of the fossil record and the lack of universal skeletal markers for age.
Xuexue Liu, Andaine Seguin-Orlando, Lorelei Chauvey, Gaëtan Tressières, Stéphanie Schiavinato, Laure Tonasso-Calvière, Jean-Marc Aury, Aude Perdereau, Stefanie Wagner, Pierre Clavel, Oscar Estrada, Jianfei Pan, Yuehui Ma, Jacob Enk, Alison Devault, Jennifer Klunk, Sébastien Lepetz, Benoit Clavel, Lin Jiang, Patrick Wincker, Yvette Running Horse Collin, Clio Der Sarkissian, Ludovic Orlando   +22 more
doaj   +1 more source

Detecting tandem repeat variants in coding regions using code-adVNTR

iScience, 2022
Summary: The human genome contains more than one million tandem repeats (TRs), DNA sequences containing multiple approximate copies of a motif repeated contiguously.
Jonghun Park, Mehrdad Bakhtiari, Bernt Popp, Michael Wiesener, Vineet Bafna   +4 more
doaj   +1 more source