Results 61 to 70 of about 5,499,417 (372)

Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update

World Journal of Gastroenterology, 2017
Gallbladder cancer is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developing countries. Late diagnosis and deprived prognosis are major problems for treatment of gallbladder
Aarti Sharma, K. L. Sharma, Annapurna Gupta, Alka Yadav, Ashok Kumar   +4 more
semanticscholar   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

ILF3 prion-like domain regulates gene expression and fear memory under chronic stress

iScience, 2023
Summary: The prion-like domain (PrLD) is a class of intrinsically disordered regions. Although its propensity to form condensates has been studied in the context of neurodegenerative diseases, the physiological role of PrLD remains unclear.
Akira Yamashita, Yuichi Shichino, Kazuki Fujii, Yumie Koshidaka, Mayumi Adachi, Eri Sasagawa, Mari Mito, Shinichi Nakagawa, Shintaro Iwasaki, Keizo Takao, Nobuyuki Shiina   +10 more
doaj   +1 more source

The Neolithic transition in Europe: archaeological models and genetic evidence [PDF]

, 2003
The major pattern in the European gene pool is a southeast-northwest frequency gradient of classic genetic markers such as blood groups, which population geneticists initially attributed to the demographic impact of Neolithic farmers dispersing from the ...
Richards, Martin B.
core   +4 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Acinetobacter baumannii biofilm was inhibited by tryptanthrin through disrupting its different stages and genes expression

iScience
Summary: Biofilm formation plays a significant role in antibiotic resistance, necessitating the search for alternative therapies against biofilm-associated infections.
Tingting Guo, Na Zhou, Liying Yang, Zichen Wang, Changchao Huan, Tao Lin, Guangyu Bao, Jian Hu, Guocai Li   +8 more
doaj   +1 more source

New insight into genetic disease : the role of trinucleotide repeat expansions [PDF]

, 1995
The development of genetics in the last few decades is replete with surprise phenomena and new findings. One such phenomenon is the trinucleotide repeat expansion, a new type of mutation first discovered in 1991.
Cuschieri, Alfred
core  

Molecular genetics of 22q11.2 deletion syndrome

American Journal of Medical Genetics. Part A, 2018
The 22q11.2 deletion syndrome (22q11.2DS) is a congenital malformation and neuropsychiatric disorder caused by meiotic chromosome rearrangements. One of the goals of this review is to summarize the current state of basic research studies of 22q11.2DS. It
B. Morrow, D. McDonald-McGinn, B. Emanuel, J. Vermeesch, P. Scambler   +4 more
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Population structure and genetic diversity of Nile tilapia (Oreochromis niloticus) using microsatellite markers from selected water bodies in southwest Ethiopia

Veterinary Medicine and Science, 2023
Background The Ethiopian southwest drainage has been designated a huge potential for fishery and aquaculture development. However, the genetic diversity of Nile tilapia along the main water bodies has yet to be uncovered.
Seid Mohammed Ahmed, Bikila Hordofa, Beira Hailu Meressa, Metekia Tamiru   +3 more
doaj   +1 more source