Results 191 to 200 of about 3,265,759 (283)

Receptogenesis in a Vascularized Robotic Embodiment

Advanced Science, EarlyView.
Functional augmentation of situated robots via ex novo hardware generation extends physical adaptability. Drawing inspiration from open circulatory systems for mass and function redistribution, this study presents a vascularized robotic composite exhibiting receptogenesis ‐ the on‐demand construction of sensors ‐ from internal fluid reserves based on ...
Kadri‐Ann Pankratov, Leonid Zinatullin, Hans Priks, Adele Metsniit, Urmas Johanson, Tarmo Tamm, Alvo Aabloo, Edoardo Sinibaldi, Indrek Must   +8 more
wiley   +1 more source

Biophysical Modeling Elucidates Mechanistic Principles for Rational Molecular Glue Design. [PDF]

J Chem Inf Model
Chae SJ, DeBonis J, Quinlan J, Richards R, Wang J, Gutierrez G, Tart J, Couturier M, Martinez Cuesta S, Jin M, Igoshin OA.   +10 more
europepmc   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome. [PDF]

Nature
Shi H, Wang X, Yu C, Mao H, Jiao F, Braitbard M, Shor B, Zhang Z, Hinds TR, Cao S, Fan E, Schneidman-Duhovny D, Huang L, Zheng N.   +13 more
europepmc   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

A Covalent Allosteric Molecular Glue Suppresses NRF2-Dependent Cancer Growth. [PDF]

Cancer Discov
Roy N, Wyseure T, Lo IC, Lu J, Eissler CL, Bernard SM, Bok I, Snead AN, Parker A, Lo UG, Green JC, Inloes J, Jacinto SR, Kuenzi B, Pariollaud M, Negri K, Le K, Horning BD, Ibrahim N, Grabow S, Panda H, Bhatt DP, Wilkerson EM, Saeidi S, Zolkind P, Rush Z, Williams HN, Walton E, Pastuszka MK, Sigler JJ, Tran E, Hee K, McLaughlin J, Ambrus-Aikelin G, Pollock J, Abraham RT, Kinsella TM, Simon GM, Major MB, Weinstein DS, Patricelli MP.   +40 more
europepmc   +1 more source

Decoupling Electronic–Ionic Transport and Catalysis Enables High‐Performance, Chemically Stable Sr‐Free Air Electrodes for High‐Temperature Solid Oxide Cells

Advanced Science, EarlyView.
A Sr‐free air electrode for high‐temperature solid oxide cells is designed by independently tailoring electronic conduction, ionic transport, and surface catalysis using complementary Sr‐free phases and infiltrated nanocatalysts. It delivers performance comparable to state‐of‐the‐art Sr‐containing electrodes while completely suppressing Cr‐induced ...
Ji‐eun Won, Wooseok Lee, Jaehyun Seo, Dogeun Yoon, Ho‐Il Ji, HeeChan Kang, Jun Hyuk Kim, Hwitae Kim, Ji Wan Kim, Jongsup Hong, Kyung Joong Yoon   +10 more
wiley   +1 more source

MGTbind: a comprehensive database of molecular glue ternary interactome. [PDF]

Nucleic Acids Res
Zhu J, Liao Y, Lin H, Xie J, Deng Z, Han J, Zhang Z, Xiao J, Wang Z, Zhang S, Lai L, Pei J.   +11 more
europepmc   +1 more source

Abstract 2025 The Glue Gimmick - Crystallization of CRBN + Neosubstrate + Molecular Glue Ternary Complexes to Improve Molecular Glue Specificity

Journal of Biological Chemistry
Be Kuehn, Sarah Young, Marcus Fischer
openaire   +1 more source

Sticker Valence Governs Chain Collapse and Liquid‐Liquid Phase Separation in Peptide‐Inspired Associative Polymers

Advanced Science, EarlyView.
Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Seung‐Hwan Oh, Jinhoon Lee, Seunghyun Lee, Raehyun Jung, Sangyeop Lee, Su‐Mi Hur, Dong Woog Lee, Soo‐Hyung Choi   +7 more
wiley   +1 more source