Results 171 to 180 of about 3,265,759 (283)

The molecular basis for nuclear pore destruction by a proximity-inducing molecular glue. [PDF]

Cell Chem Biol
Hinshaw SM, Yuan L, Noman MAA, Martinez MJ, Colombo GM, Dwyer BG, Ji W, Romero BA, Forrest I, Lu J, Bian J, Dunn TB, Garvin ER, Fernandez D, Zhang T, Gray NS, Corsello SM.   +16 more
europepmc   +1 more source

Isomeric Ag14 Nanoclusters With Distinct Photophysical and Nanomechanical Properties

Advanced Science, EarlyView.
Ligand‐shell isomerism in atomically precise Ag14 nanoclusters is demonstrated to regulate core distortion, photoluminescence, and mechanical properties. Subtle changes in phosphine ligand arrangement drive a pronounced emission shift from green to red and alter crystal rigidity, revealing a direct structure‐property correlation that offers new design ...
Vivek Yadav, Arijit Jana, Maya Khatun, Harshita Nagar, Sergei Lebedkin, Amit Mondal, Swetashree Acharya, Sami Malola, Sudhadevi Antharjanam, Moses Egor, Pijush Ghosh, Tomas Base, Manfred Kappes, Hannu Häkkinen, Thalappil Pradeep   +14 more
wiley   +1 more source

Selective and Potent First-in-Class CRBN-Dependent Molecular Glue Degraders of WW Domain-Binding Protein 4. [PDF]

Angew Chem Int Ed Engl
Liu Y, Chen L, Peng B, Zeng P, Cao L, Huang L, Zhou L, Yang S, Wang J, Sun Y, Chen L, Feng Y, Shi T, Chen Q, Zhao K, Lu J, Jiang B, Lu W.   +17 more
europepmc   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer. [PDF]

Nature
Lu X, Wang X, Yang Z, Wang X, Wang L, Xu C, Lo IC, Geng C, Wang L, Pu Y, Zhang K, Zhu Z, Ye L, Huang J, Wei X, Bai F, Zhu Y, Qian X, Dou H, Su H, Cang Y.   +20 more
europepmc   +1 more source

Phonon‐Driven Tetrahedral Tilts Enable Ultralow Bulk Thermal Expansion and Interstitial Oxide‐Ion Migration in Phenacite Solid Electrolytes

Advanced Science, EarlyView.
This work demonstrates a design paradigm of phonon‐driven negative‐thermal‐expansion (NTE) flexible framework that exploits the intrinsic lattice flexibility of NTE frameworks to simultaneously suppress thermal expansion and activate oxide‐ion conduction, offering a promising strategy to mitigate TEC mismatch in solid‐state ionic devices.
Xiaohui Li, Lu liang, Qilong Shi, Xiaoge Wang, Cheng Li, Sihao Deng, Lunhua He, Qiang Li, Kun Lin, Xianran Xing, Xiaojun Kuang   +10 more
wiley   +1 more source

Molecular glue that stabilizes the LRPPRC-MET-G4 interaction complex to drive MET downregulation. [PDF]

Nat Commun
Li YP, Zheng Y, Liu YS, Zhang LF, Chen XY, He SH, Chen JN, Cheng RS, Wang Y, Wang YY, Tang L, Zheng KW, Xu ST, Bian JL, Zhang H, Wang KB, Kong LY.   +16 more
europepmc   +1 more source

Single‐Atom‐Enhanced Fully Inkjet‐Printed Electrochemical Sensor for Dopamine Detection

Advanced Science, EarlyView.
Fully inkjet‐printed paper‐based dopamine sensors are fabricated using nitrogen‐doped graphene acid functionalized with copper single atoms. The copper sites uniquely enhance dopamine oxidation through strong molecular adsorption, as verified by electrochemical measurements and DFT calculations. The approach highlights the potential of single‐atom inks
Martin‐Alex Nalepa, David Panáček, Vítězslav Hrubý, Matěj Jendrišák, Rostislav Langer, Michal Langer, Petr Jakubec, Ivan Dědek, Vojtěch Kupka, Michal Mazur, Radek Zbořil, Michal Otyepka   +11 more
wiley   +1 more source

Charged molecular glue discovery enabled by targeted degron display. [PDF]

Nat Chem Biol
Zhuang Z, Byun WS, Chrustowicz J, Kozicka Z, Li VL, Abeja DM, Donovan KA, Sepic S, You I, Słabicki M, Fischer ES, Hinshaw SM, Ebert BL, Schulman BA, Gray NS.   +14 more
europepmc   +1 more source