Results 151 to 160 of about 3,265,759 (283)

DCAF11-dependent molecular glue degrader activated by glutathionylation. [PDF]

Nature
Yoon H, Wachter F, Barrett KA, Jin C, Rodríguez-Pöhnlein A, Rutter JC, Lumpkin RJ, Metivier RJ, Donovan KA, Baek K, Jiang Y, Lee M, Kalis RW, Che J, Xiong Y, Fischer ES, Ebert BL.   +16 more
europepmc   +1 more source

3D Printing of Self‐Healing Polymers by Material Extrusion: A Process‐Centric Review of Setups, Parameters, and Applications

Advanced Robotics Research, EarlyView.
This review highlights recent advances in material extrusion 3D printing of self‐healing polymers, focusing on the interplay between material chemistry, rheology, hardware customization, and process optimization. Filament‐ and ink‐based extrusion strategies, multimaterial architectures, and postprocessing approaches are discussed for applications in ...
Antonio Pavone, Gianni Stano, Gianluca Percoco   +2 more
wiley   +1 more source

Leveraging efficiency metrics for the optimization of CELMoDs\u2122 as cereblon-based molecular glue degraders

Efficiency metrics are useful in medicinal chemistry to track small molecule progress in lead optimization (LO). Molecular glue degraders are small molecules that mediate targeted protein degradation by chemically inducing proximity between an E3 ligase ...
Zapf, Christoph W., Claus, Brian L., Johnson, Stephen R., Shanmugasundaram, Veerabahu, Weiss, Dahlia R., Jia, Lei, Riggs, Jennifer R.   +6 more
core   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Structure-Guided Optimization of a Molecular Glue Targeting the KBTBD4-HDAC1/2 Complex. [PDF]

ChemMedChem
Balo T, Chen Z, Palluaud L, Kiss A, Novak T, Herner A, Bullock AN, Martiny V, Kotschy A.   +8 more
europepmc   +1 more source

From Pores to Pavement: Advanced Modeling of Aluminosilicates for Scalable Carbon Capture in Concrete

Advanced Science, EarlyView.
This study presents a transferable modeling framework for carbon capture using aluminosilicates, integrating Universal Isotherm Modeling with experimental data. It reveals how ultramicropores, alumina content, and amine functionalization influence CO2 adsorption energetics.
Pooja Anil Kumar Nair, Jéssica de O. N. Ribeiro, Murilo Daniel de Mello Innocentini, Kevin Paine, Juliana Calabria‐Holley   +4 more
wiley   +1 more source

A biased allosteric modulator is a molecular glue for β₂AR dimerization. [PDF]

Nature
Shen J, Peddada TN, Komolov KE, De Pascali F, Garces AM, Wang H, Ehsan M, Chae PS, Lerch MT, Benovic JL, Xu J, Kobilka BK.   +11 more
europepmc   +1 more source

A molecular glue to take down mutant BRAF

A molecular glue degrader tackles mutant BRAF in drug-resistant colorectal cancer by disrupting mRNA splicing.
Leslie K. Ferrarelli
core   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

A molecular glue induces aberrant STING oligomerization and inhibits autoinflammatory diseases. [PDF]

Signal Transduct Target Ther
Feng ZW, Zeng T, Shu Q, Li XZ, Yu HG, Dai W, Liu XC, Tian XJ, Xu F, Li H, Zhou YL, Zhang SD, Li LL, Chen NN, Liu XY, Liu ZW, Yin J, Shen HT, Che CC, Chen MR, Wang DD, Sun LY, Xiao YB, You QD, Xu XL.   +24 more
europepmc   +1 more source