Results 131 to 140 of about 3,265,759 (283)

Evaluation of molecular glue–induced neomorphic protein-protein interaction with a cell lysate–based time-resolved fluorescence resonance energy transfer assay

ASPET Discovery
Neomorphic protein-protein interactions (neoPPIs) induced by mutated amino acid residues present a promising class of therapeutic targets for proximity pharmacology-enabled drug discovery. Small molecule compounds, such as cyclosporin and FK506, have the
Xiulei Mo, Yuhong Du, Haian Fu
doaj   +1 more source

Molecular Glue Degraders Enhance CAPRIN1-Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease. [PDF]

Adv Sci (Weinh)
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Jung S, Wang X, Liu B, Roy R, Jaiswal N, Rai RK, Takagi Y, Gao C, Zeng L, Lo HY, Wohlford RK, Higgins RK, Lamb BT, Shekhar A, Bellail AC, Hao C.   +15 more
europepmc   +2 more sources

Ferrocene‐Based Self‐Assembled Monolayers Enable Ultra‐High Specific Detectivity in Perovskite Photodetectors

Advanced Materials, EarlyView.
We report perovskite photodetectors with record specific detectivities exceeding 1013 Jones with a novel molecular design strategy to functionalize self‐assembled monolayers (SAMs) with ferrocene (Fc) derivatives. Fc‐SAM‐based devices also exhibit strong operational stability and enable data transmission rates exceeding 1 Mbps in a LiFi system ...
Edoardo Angela, William D. J. Tremlett, Francesco Vanin, William J. O. Rodriguez Kazeem, Zhuoran Qiao, Davide Nodari, Francesco Furlan, Zonglong Zhu, Martyn A. McLachlan, Nicholas J. Long, Nicola Gasparini   +10 more
wiley   +1 more source

Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha

Nature Communications
Target identification in natural products plays a critical role in the development of innovative drugs. Bufalin, a compound derived from traditional medicines, has shown promising anti-cancer activity; however, its precise molecular mechanism of action ...
Shilong Jiang, Keyi Liu, Ting Jiang, Hui Li, Xiao Wei, Xiaoya Wan, Changxin Zhong, Rong Gong, Zonglin Chen, Chan Zou, Qing Zhang, Yan Cheng, Dongsheng Cao   +12 more
doaj   +1 more source

Interface‐Mediated Catalysis for Improved Hydrogen Storage in Reactive Hydride Composites

Advanced Materials, EarlyView.
Catalyst–hydride interfaces are engineered in Co@C‐ and Ni@C‐modified 2LiH + MgB2 reactive hydride composites to accelerate hydrogen uptake and release. Multiscale scattering, in‐situ synchrotron radiation powder x‐ray diffraction and density functional theory calculations reveal the structural and electronic origin of the catalytic enhancement ...
Yuanyuan Shang, Pawan Kumar Soni, Han Ge, Weijie Yang, Fahim Karimi, Thi Thu Le, Tamás Simon, Michael Fröba, Jitendra Mata, Joshua King, Hai‐Wen Li, Thomas Klassen, Claudio Pistidda   +12 more
wiley   +1 more source

Mimicry of molecular glues using dual covalent chimeras

Nature Communications
A special class of proximity inducing bifunctional molecules/chimeras called molecular glues leverage positive co-operativity to stabilize ternary complex formation and induce a biological response.
Eden Kapcan, Karolina Krygier, Maya da Luz, Nickolas J. Serniuck, Ali Zhang, Jonathan Bramson, Anthony F. Rullo   +6 more
doaj   +1 more source

Abstract A054: Molecular glue discovery enabled by targeted degron display

Small molecules that induce protein interactions hold tremendous potential as new medicines, as probes for molecular pathways, and as tools for agriculture. Explosive growth of targeted protein degradation drug development has spurred renewed interest in
Zhe Zhuang
core   +1 more source

Defect‐Driven Charge Separation in Ba‐Doped SrTiO3: Correlating Photoelectrochemical Performance With Dye‐Selective Photocatalysis

Advanced Materials Interfaces, EarlyView.
Ba‐doped SrTiO3 perovskites establish a direct correlation between photoelectrochemical activity and photocatalytic performance. Optimized Ba0.5Sr0.5TiO3 exhibits enhanced charge separation, photocurrent generation, and visible‐light‐driven dye degradation through defect‐induced oxygen vacancies and lattice distortion.
Sagar A. Nikam, Somnath Ladhane, Vikas P. Mhaske, Gotan H. Jain, Sandesh R. Jadkar, Shashikant P. Patole, Ganesh E. Patil   +6 more
wiley   +1 more source

An Entirely New Molecular Glue for MOF Using Unusual Structural Transformation of a Coordination Polymer [PDF]

, 2018
In this research, an entirely new molecular glue is reported. This ‘coordination polymer glue’ is synthesized from zinc metal and BDC-NPE(2,5-bis{4-[1-(4-nitrophenyl)ethylamino]butoxy}terephthalic acid).
Jung, Sukwoo, Ahn, Junseok, Kim, Hangyeol   +2 more
core  

Surface Functionalization Modulates Collective Cell Behavior Near Topological Defects Induced by Topographical Patterning

Advanced Materials Interfaces, EarlyView.
Strongly adhered cells align with concentric circular ridges and exhibit predominantly tangential motion, whereas weakly adhered cells fail to follow topographical guidance and display enhanced radial inward motion. ABSTRACT Living cells establish long‐range orientational order through collective alignment, giving rise to topological defects whose ...
Prasoon Awasthi, Aniruddh Murali, Ellen Juel Pørtner, Adam Cohen Simonsen, Francesca Serra   +4 more
wiley   +1 more source