Results 91 to 100 of about 4,217,992 (292)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Topological edge properties of C60+12n fullerenes
Beilstein Journal of Nanotechnology, 2013 A molecular graph M is a simple graph in which atoms and chemical bonds are the vertices and edges of M, respectively. The molecular graph M is called a fullerene graph, if M is the molecular graph of a fullerene molecule.
A. Mottaghi, Ali R. Ashrafi
doaj +1 more source
Total and Double Total Domination Number on Hexagonal Grid
Mathematics, 2019 In this paper, we determine the upper and lower bound for the total domination number and exact values and the upper bound for the double-total domination number on hexagonal grid H m , n with m hexagons in a row and n hexagons in a column ...
Antoaneta Klobučar, Ana Klobučar
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Eccentricity-Based Topological Indices of a Cyclic Octahedron Structure
Mathematics, 2018 In this article, we study the chemical graph of a cyclic octahedron structure of dimension n and compute the eccentric connectivity polynomial, the eccentric connectivity index, the total eccentricity, the average eccentricity, the first Zagreb index ...
Manzoor Ahmed Zahid +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
On Pathos Semitotal and Total Block Graph of a Tree [PDF]
, 2011 The concept of pathos of a graph G was introduced by Harary [2], as a collection of minimum number of line disjoint open paths whose union is G. The path number of a graph G is the number of paths in pathos.
Muddebihal M. H.
core +1 more source
Valency-based molecular descriptors of Bakelite network BNmn$B\text N_{m}^{n}$
Open Chemistry, 2019 Bakelite network BNmn$BN_{m}^{n}$is a molecular graph of bakelite, a pioneering and revolutionary synthetic polymer (Thermosetting Plastic) and regarded as the material of a thousand uses. In this paper, we aim to compute various degree-based topological
Ahmad Maqsood +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source