Results 151 to 160 of about 455,903 (307)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Incorporating Retrieval-based Causal Learning with Information Bottlenecks for Interpretable Molecular Graph Learning [PDF]

Jiahua Rao, Hanjing Lin, Jiancong Xie, Zhen Wang, Shuangjia Zheng, Yuedong Yang   +5 more
openalex   +1 more source

MHG-GNN: Combination of Molecular Hypergraph Grammar with Graph Neural Network [PDF]

, 2023
Akihiro Kishimoto, Hiroshi Kajino, Masataka Hirose, Junta Fuchiwaki, Indra Priyadarsini, Lisa Hamada, Hajime Shinohara, Daiju Nakano, Seiji Takeda   +8 more
openalex   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

3D-GSRD: 3D Molecular Graph Auto-Encoder with Selective Re-mask Decoding [PDF]

Chang Wu, Zhiyuan Liu, Wen Shu, Liang Wang, Yanchen Luo, Wenqiang Lei, Yatao Bian, Junfeng Fang, Xiang Wang   +8 more
openalex   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Molassembler: Molecular Graph Construction, Modification, and Conformer Generation for Inorganic and Organic Molecules. [PDF]

J Chem Inf Model, 2020
Sobez JG, Reiher M.
europepmc   +1 more source

Generating Molecular Fragmentation Graphs with Autoregressive Neural Networks [PDF]

, 2023
Samuel Goldman, Janet Li, Connor W. Coley   +2 more
openalex   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Improving hERG Cardiotoxicity Prediction via SMILES Transformer, Molecular Fingerprints, and Layer-Wise Self-Adaptive Graph Attention Network [PDF]

Cheikh Beidja, Abdelmajid Bousselham, Zakariae En-Naimani, Mohammed Mestari   +3 more
openalex   +1 more source