Results 31 to 40 of about 3,947,894 (203)

Advancing glioblastoma treatment by targeting metabolism

Neoplasia: An International Journal for Oncology Research
Alterations in cellular metabolism are important hallmarks of glioblastoma(GBM). Metabolic reprogramming is a critical feature as it meets the higher nutritional demand of tumor cells, including proliferation, growth, and survival.
Jinyi Zhao, Xuemei Ma, Peixian Gao, Xueqi Han, Pengxiang Zhao, Fei Xie, Mengyu Liu   +6 more
doaj   +1 more source

Effects of molecular hydrogen supplementation on fatigue and aerobic capacity in healthy adults: A systematic review and meta-analysis

Frontiers in Nutrition, 2023
BackgroundFatigue is oftentimes induced by high-intensity exercise potentially via the exceeded amount of reactive oxygen species, leading to diminished functions (e.g., aerobic capacity) and increased risk of injuries.
Kaixiang Zhou, Meng Liu, Yubo Wang, Haoyang Liu, Brad Manor, Dapeng Bao, Luyu Zhang, Junhong Zhou   +7 more
doaj   +1 more source

The endogenous production of hydrogen sulphide in intrauterine tissues [PDF]

, 2009
Background: Hydrogen sulphide is a gas signalling molecule which is produced endogenously from L-cysteine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).
Patel Pushpa, Carson Ray J, Patel, Pushpa, Heptinstall, John, Heptinstall, J, Wang, Rui, Carson, RJ, Rui Wang, John Heptinstall (7594472), Pushpa Patel, Carson, Ray J., Pushpa Patel (2697712), Heptinstall John, Rui Wang (52434), Vatish Manu, Vatish, M, Ray J Carson, Manu Vatish (187260), Wang Rui, Wang, R, Ray J. Carson (7594475), Vatish, Manu, Manu Vatish, John Heptinstall   +23 more
core   +1 more source

Mast Cells in Regeneration of the Skin in Burn Wound with Special Emphasis on Molecular Hydrogen Effect

Pharmaceuticals, 2023
The mechanisms of regeneration for the fibrous component of the connective tissue of the dermis are still insufficiently studied. The aim of this study was to evaluate the effectiveness of the use of molecular hydrogen on the local therapy of a II degree
Dmitri Atiakshin, Mariya Soboleva, Dmitry Nikityuk, Nataliya Alexeeva, Svetlana Klochkova, Andrey Kostin, Viktoriya Shishkina, Igor Buchwalow, Markus Tiemann   +8 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

GSTA1/CTNNB1 axis facilitates sorafenib resistance via suppressing ferroptosis in hepatocellular carcinoma

Pharmacological Research
The emergence of sorafenib resistance has become a predominant impediment and formidable dilemma in the therapeutic approach for hepatocellular carcinoma (HCC).
Shiwen Ma, Fei Xie, Xiaohu Wen, Yao Mawulikplimi Adzavon, Ruping Zhao, Jinyi Zhao, Han Li, Yanqi Li, Jingtao Liu, Chen Liu, Yang Yi, Pengxiang Zhao, Boqing Wang, Wei Zhao, Xuemei Ma   +14 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Incorporation of molecular hydrogen into solvents increases the extraction efficiency of phenolics, flavonoids, anthocyanins, and antioxidants: the case of lemon peels

Frontiers in Sustainable Food Systems, 2023
The impact of hydrogen infusion into solvents on the extraction of phytochemicals was evaluated. Pure (water, ethanol, methanol) and hydrogen-rich solvents at temperatures (25°C and 35°C) were used for extracting phenolics, flavonoids, anthocyanins, and ...
Duried Alwazeer, Duried Alwazeer, Duried Alwazeer, Muhammed Allam Elnasanelkasim, Muhammed Allam Elnasanelkasim, Ayhan Çiğdem, Ayhan Çiğdem, Tunahan Engin, Tunahan Engin, Tyler W. LeBaron, Tyler W. LeBaron   +10 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Cross Section for Production of Excited Hydrogen Atoms Following Dissociative Excitation of Molecular Hydrogen by Electron Impact [PDF]

, 1990
For the purpose of investigating molecular hydrogen present in plasmas, the production cross section of excited hydrogen atoms due to dissociative excitation of molecular hydrogen by electron collisions has been estimated from the emission cross sections
FUJIMOTO, Takashi, TAKAHATA, Kiyoto, SAWADA, Keiji   +2 more
core