Results 1 to 10 of about 3,022,035 (311)

CCK1R2R-/- ameliorates myocardial damage caused by unpredictable stress via altering fatty acid metabolism

open access: yesStress, 2023
The heart is the main organ of the circulatory system and requires fatty acids to maintain its activity. Stress is a contributor to aggravating cardiovascular diseases and even death, and exacerbates the abnormal lipid metabolism.
Zhi-Hua Zhang   +6 more
doaj   +1 more source

Dynamic Changes in Plasma Metabolic Profiles Reveal a Potential Metabolite Panel for Interpretation of Fatal Intoxication by Chlorpromazine or Olanzapine in Mice

open access: yesMetabolites, 2022
Diagnosing the cause of fatal intoxication by antipsychotic agents is an important task in forensic practice. In the 2020 Annual Report of the American Association of Poison Control Centers, among 40 deaths caused by antipsychotics, 21 cases were ...
Rui Bai   +7 more
doaj   +1 more source

Inhibitory Effect of CCK-8 on Methamphetamine-Induced Apoptosis

open access: yesFayixue Zazhi, 2021
ObjectiveTo investigate the inhibitory effect of cholecystokinin octapeptide (CCK-8) binding to cholecystokinin 2 receptor (CCK2R) on methamphetamine (METH)-induced neuronal apoptosis, and to explore the signal transduction mechanism of β-arrestin 2 in ...
ZHANG Wu-hua   +8 more
doaj   +1 more source

Endoplasmic Reticulum Stress Is Involved in Glucocorticoid-Induced Apoptosis in PC12 Cells

open access: yesAnalytical Cellular Pathology, 2021
Objective. The present study selected PC12 cells to construct a neuronal injury model induced by glucocorticoids (GC) in vitro, aiming to explore whether the endoplasmic reticulum stress (ERS) PKR-like endoplasmic reticulum kinase (PERK)-activating ...
Shanyong Yi   +7 more
doaj   +1 more source

The Pathology of Morphine-Inhibited Nerve Repair and Morphine-Induced Nerve Damage Is Mediated via Endoplasmic Reticulum Stress

open access: yesFrontiers in Neuroscience, 2021
ObjectiveThe aim of the present study was to observe the pathological damage in the cerebral cortex of rats under acute morphine exposure (AME) and different durations of morphine dependence (MD), explore whether endoplasmic reticulum stress (ERS) is ...
Jie Liu   +9 more
doaj   +1 more source

The amino acid metabolomics signature of differentiating myocardial infarction from strangulation death in mice models

open access: yesScientific Reports, 2023
This study differentiates myocardial infarction (MI) and strangulation death (STR) from the perspective of amino acid metabolism. In this study, MI mice model via subcutaneous injection of isoproterenol and STR mice model by neck strangulation were ...
Song-Jun Wang   +7 more
doaj   +1 more source

A Metabolomics-Based Study on the Discriminative Classification Models and Toxicological Mechanism of Estazolam Fatal Intoxication

open access: yesMetabolites, 2023
Fatal intoxication with sedative-hypnotic drugs is increasing yearly. However, the plasma drug concentration data for fatal intoxication involving these substances are not systematic and even overlap with the intoxication group.
Xiaohui Dai   +9 more
doaj   +1 more source

Analysis of Five Mushroom Toxins in Blood by UPLC-HRMS

open access: yesFayixue Zazhi, 2021
ObjectiveTo develop a method for the simultaneous and rapid detection of five mushroom toxins (α-amanitin, phallacidin, muscimol, muscarine and psilocin) in blood by ultra-high performance liquid chromatography-high resolution mass spectrometry (UPLC ...
LIU Wen-qiao   +8 more
doaj   +1 more source

Epidemiological Characteristics of Sedative-Hypnotics and Opioid Painkillers at High-Frequency Exposure

open access: yesFayixue Zazhi, 2021
Drug poisoning has a high incidence and serious consequences in medical institutions; its epidemiological characteristics also directly affect the changes in national laws and policies and the implementation of local management policies.
BAI Rui   +4 more
doaj   +1 more source

From mass to structure: An aromaticity index for high-resolution mass data of natural organic matter [PDF]

open access: yes, 2006
Recent progress in Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS) provided extensive molecular mass data for complex natural organic matter (NOM). Structural information can be deduced solely from the molecular masses for ions with
Benecke   +16 more
core   +1 more source

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