Results 21 to 30 of about 3,022,035 (311)

Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats

Analytical Cellular Pathology, 2021
An increasing number of people are in a state of stress due to social and psychological pressures, which may result in mental disorders. Previous studies indicated that mesencephalic dopaminergic neurons are associated with not only reward-related ...
Shiba Niu, Weibo Shi, Yingmin Li, Shanyong Yi, Yang Li, Xia Liu, Bin Cong, Guanglong He   +7 more
doaj   +1 more source

Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment

Frontiers in Pharmacology, 2019
Methamphetamine (METH) is a highly addictive stimulant, and METH exposure can induce irreversible neuronal damage and cause neuropsychiatric and cognitive disorders.
Di Wen, Rongji Hui, Jian Wang, Xi Shen, Bing Xie, Miao Gong, Feng Yu, Bin Cong, Chunling Ma   +8 more
doaj   +1 more source

Zinc chloride-catalyzed cyclizative 1,2-rearrangement enables facile access to morpholinones bearing aza-quaternary carbons

Communications Chemistry, 2023
Morpholines and morpholinones are important building blocks in organic synthesis and pharmacophores in medicinal chemistry, however, C3-disubstituted morpholines/morpholinones are extremely difficult to access.
Xing-Zi Li, Yu-Ping He, Hua Wu
doaj   +1 more source

Theory and Application of Dissociative Electron Capture in Molecular Identification [PDF]

, 2006
The coupling of an electron monochromator (EM) to a mass spectrometer (MS) has created a new analytical technique, EM-MS, for the investigation of electrophilic compounds.
Clougherty, Dennis P., Cody, Robert B., Eberhart, Mark, Havey, C. D., Jones, T., Laramee, James A., Voorhees, Kent J.   +6 more
core   +2 more sources

Genome-inspired molecular identification in organic matter via Raman spectroscopy

, 2016
Rapid, non-destructive characterization of molecular level chemistry for organic matter (OM) is experimentally challenging. Raman spectroscopy is one of the most widely used techniques for non-destructive chemical characterization, although it currently ...
Bryndzia, L. Taras, Ferralis, Nicola, Grossman, Jeffrey C., Liu, Yun   +3 more
core   +1 more source

Restraint Stress Induced Hyperpermeability and Damage of the Blood-Brain Barrier in the Amygdala of Adult Rats

Frontiers in Molecular Neuroscience, 2019
Intense or prolonged exposure to stress can damage various brain structures, including the amygdala and hippocampus, which are associated with emotional-cognitive functions. Furthermore, this deterioration has been linked to a myriad of neurodegenerative
Guangming Xu, Yingmin Li, Chunling Ma, Chuan Wang, Zhaoling Sun, Yiwen Shen, Li Liu, Shujin Li, Xiaojing Zhang, Bin Cong   +9 more
doaj   +1 more source

In-silico guided chemical exploration of KDM4A fragments hits

Clinical Epigenetics, 2023
Background Lysine demethylase enzymes (KDMs) are an emerging class of therapeutic targets, that catalyse the removal of methyl marks from histone lysine residues regulating chromatin structure and gene expression. KDM4A isoform plays an important role in
Jessica Lombino, Rosario Vallone, Maura Cimino, Maria Rita Gulotta, Giada De Simone, Maria Agnese Morando, Raffaele Sabbatella, Simona Di Martino, Mario Fogazza, Federica Sarno, Claudia Coronnello, Maria De Rosa, Chiara Cipollina, Lucia Altucci, Ugo Perricone, Caterina Alfano   +15 more
doaj   +1 more source

Identification of botanicals using molecular biotechnology

Polymers in Medicine, 2023
The available information on the abundance of restorative plants on earth is incomplete, and the data regarding botanicals from various countries differ significantly. The substantial development of the worldwide natural botanical market is attributable to the expanding revenue of global drug companies trading herbal medicines.
Mohd Imran, Tasha Riaz, Haya Majid, Shayan Maqsood   +3 more
openaire   +2 more sources

The Role of circTmeff-1 in Morphine Addiction Memory of Mice

Cells, 2023
In addition to the essential pharmacological effects of opioids, situational cues associated with drug addiction memory are key triggers for drug seeking.
Hailei Yu, Boyang Wen, Yun Lu, Bing Xie, Feng Yu, Minglong Zhang, Chunling Ma, Bin Cong, Di Wen, Haitao Bi   +9 more
doaj   +1 more source

New model for datasets citation and extraction reproducibility in VAMDC

, 2016
In this paper we present a new paradigm for the identification of datasets extracted from the Virtual Atomic and Molecular Data Centre (VAMDC) e-science infrastructure.
Dubernet, Marie-Lise, Moreau, Nicolas, Zwölf, Carlo Maria   +2 more
core   +3 more sources