Results 21 to 30 of about 7,162,052 (308)

Determination of barbiturates in hair samples by using a validated UHPLC-HRMS method: application in investigation of drug-facilitated sexual assault

open access: yesForensic Sciences Research, 2019
In recent years, benzodiazepines and benzodiazepine-like drugs are the most common substances associated with drug-facilitated sexual assaults (DFSA); however, barbiturates are also detected occasionally.
Di Wen   +8 more
doaj   +1 more source

Metabolomics Changes of Serum and Tissues in Mice Died of Acute Tetracaine Poisoning [PDF]

open access: yesFayixue Zazhi, 2021
Objective To study the changes of metabolites in serum and tissues (kidney, liver and heart) of mice died of acute tetracaine poisoning by metabolomics, to search for potential biomarkers and related metabolic pathways, and to provide new ideas for the ...
LIU Wen-qiao, BAI Rui, MA Chun-ling, et al.
doaj   +1 more source

Molecular Identification of a Mechanosensitive Channel in Archaea [PDF]

open access: yesBiophysical Journal, 2001
The TM1 domain of the large conductance mechanosensitive (MS) channel of Escherichia coli was used as a genetic probe to search the genomic database of the archaeon Methanoccoccus jannashii for MscL homologs. We report that the hypothetical protein MJ0170 of M. jannashii exhibited 38.5% sequence identity with the TM1 domain of Eco-MscL.
Kloda, A., Martinac, B.
openaire   +4 more sources

Molecular Approaches to the Identification [PDF]

open access: yesEmerging Infectious Diseases, 1996
New molecular biologic techniques, particularly representational difference analysis, consensus sequence-based polymerase chain reaction, and complementary DNA library screening, have led to the identification of several previously unculturable infectious agents.
Shou-Jiang Gao, Patrick S. Moore
openaire   +3 more sources

Berberine Facilitates Extinction of Drug-Associated Behavior and Inhibits Reinstatement of Drug Seeking

open access: yesFrontiers in Pharmacology, 2020
A high rate of relapse is a major clinical problem among drug-addicted individuals. Persistent traces of drug-associated reward memories contribute to intense craving and often trigger relapse.
Xi Shen   +10 more
doaj   +1 more source

Comparison of quantitative real time PCR with Sequencing and ribosomal RNA-FISH for the identification of fungi in Formalin fixed, paraffin-embedded tissue specimens [PDF]

open access: yes, 2011
Background: Identification of the causative agents of invasive fungal infections (IFI) is critical for guiding antifungal therapy. Cultures remain negative in a substantial number of IFI cases.
Rickerts Volker   +17 more
core   +2 more sources

Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats

open access: yesAnalytical Cellular Pathology, 2021
An increasing number of people are in a state of stress due to social and psychological pressures, which may result in mental disorders. Previous studies indicated that mesencephalic dopaminergic neurons are associated with not only reward-related ...
Shiba Niu   +7 more
doaj   +1 more source

Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment

open access: yesFrontiers in Pharmacology, 2019
Methamphetamine (METH) is a highly addictive stimulant, and METH exposure can induce irreversible neuronal damage and cause neuropsychiatric and cognitive disorders.
Di Wen   +8 more
doaj   +1 more source

Zinc chloride-catalyzed cyclizative 1,2-rearrangement enables facile access to morpholinones bearing aza-quaternary carbons

open access: yesCommunications Chemistry, 2023
Morpholines and morpholinones are important building blocks in organic synthesis and pharmacophores in medicinal chemistry, however, C3-disubstituted morpholines/morpholinones are extremely difficult to access.
Xing-Zi Li, Yu-Ping He, Hua Wu
doaj   +1 more source

Identification of the Kna/Knb polymorphism and a method for Knops genotyping [PDF]

open access: yes, 2004
DNA mutations resulting in the McCoy and Swain-Langley polymorphisms have been identified on complement receptor 1 (CR1)-a ligand for rosetting of Plasmodium falciparum-infected RBCs. The molecular identification of the Kna/Knb polymorphism was sought to
Moulds, J M   +7 more
core   +1 more source

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