Results 91 to 100 of about 11,582,729 (334)

Recent advances in molecular imaging with gold nanoparticles.

Bioconjugate chemistry, 2019
Gold nanoparticles (AuNP) have been extensively developed as contrast agents, theranostic platforms and probes for molecular imaging. This popularity has yielded a large number of AuNP designs that vary in size, shape, surface functionalization and ...
M. Bouché, Jessica C. Hsu, Y. Dong, Johoon Kim, K. Taing, D. Cormode   +5 more
semanticscholar   +1 more source

Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1

FEBS Letters, EarlyView.
Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji, Kosuke Shiraishi, Chuqian Wang, Hiroya Yurimoto, Yasuyoshi Sakai, Masahide Oku   +5 more
wiley   +1 more source

Accomplishments and challenges in stem cell imaging in vivo. [PDF]

, 2019
Stem cell therapies have demonstrated promising preclinical results, but very few applications have reached the clinic owing to safety and efficacy concerns.
Bose, Rajendran JC, Mattrey, Robert F
core  

Spitzer Observations of Planetary Nebulae [PDF]

, 2011
The Spitzer Space Telescope has three science instruments (IRAC, MIPS, and IRS) that can take images at 3.6, 4.5, 5.8, 8.0, 24, 70, and 160 microns, spectra over 5--38 microns, and spectral energy distribution over 52--100 microns.
Bernard Salas, Corradi, Perea-Calderón, Phillips, Pottasch, Pottasch, Pottasch, Pottasch, Quino-Mendoza, Stasińska, Su, You-Hua Chu   +11 more
core   +1 more source

Molecular imaging of fibrosis: recent advances and future directions

Journal of Clinical Investigation, 2019
Fibrosis, the progressive accumulation of connective tissue that occurs in response to injury, causes irreparable organ damage and may result in organ failure.
Sydney B. Montesi, Pauline Désogère, B. Fuchs, P. Caravan   +3 more
semanticscholar   +1 more source

Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176—based on recent publications that measured specific-to-non-displaceable ratios

EJNMMI Research, 2017
Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four 11C-labeled ligands—(R)-PK11195, PBR28, DPA-713, and ER176—to quantify ...
Masahiro Fujita, Masato Kobayashi, Masamichi Ikawa, Roger N. Gunn, Eugenii A. Rabiner, David R. Owen, Sami S. Zoghbi, Mohamad B. Haskali, Sanjay Telu, Victor W. Pike, Robert B. Innis   +10 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo [PDF]

, 2017
While the use of bioluminescent proteins for molecular imaging is a powerful technology to further our understanding of complex processes, fluorescent labeling with visible light fluorescent proteins such as GFP and RFP suffers from poor tissue ...
Blyth, Karen, Cheung, Eric C., Hock, Andreas K., Humpton, Timothy J., Lee, Pearl, McGhee, Ewan, Monteverde, Tiziana, Murphy, Daniel J., Paulus-Hock, Viola, Scopelliti, Alessandro, Strathdee, Douglas, Vousden, Karen H.   +11 more
core   +1 more source

Aminolysis-mediated single-step surface functionalization of poly (butyl cyanoacrylate) microbubbles for ultrasound molecular imaging

Journal of Nanobiotechnology
Molecular ultrasound imaging with actively targeted microbubbles (MB) proved promising in preclinical studies but its clinical translation is limited. To achieve this, it is essential that the actively targeted MB can be produced with high batch-to-batch
Junlin Chen, Bi Wang, Anshuman Dasgupta, Céline Porte, Lisa Eckardt, Jinwei Qi, Marek Weiler, Twan Lammers, Anne Rix, Yang Shi, Fabian Kiessling   +10 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source