Results 111 to 120 of about 5,958,984 (296)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Affibody-Modified Gd@C-Dots with Efficient Renal Clearance for Enhanced MRI of EGFR Expression in Non-Small-Cell Lung Cancer [Corrigendum]

International Journal of Nanomedicine
Wu Y, Li H, Yan Y, et al. Int J Nanomedicine. 2020;15:4691—4703. The authors have advised due to an error that occurred inadvertently at the time of figure assembly, the MRI images at the 2 hour time point in Figure 6A and the 10 minute time ...
Wu Y, Li H, Yan Y, Wang K, Cheng Y, Li Y, Zhu X, Xie J, Sun X   +8 more
doaj  

Bacteria-cancer interactions: bacteria-based cancer therapy

Experimental and Molecular Medicine, 2019
Cancer: tumor-targeting bacteria enter the anticancer arsenal Live tumor-targeting bacteria can selectively induce cancer regression and, with the help of genetic engineering, be made safe and effective vehicles for delivering drugs to tumor cells.
Mai Thi-Quynh Duong, Yeshan Qin, Sung-Hwan You, Jung-Joon Min   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Photoacoustic imaging of micro-calcifications

, 2014
[[abstract]]Breast microcalcifications are one of the important indicators for early breast cancer detection. Currently, X-ray mammography and ultrasound imaging are routine diagnostic tools in clinics for breast cancer; however, X-ray mammography is ...
M.-L. Li;T.-C. Hsiao;P.-H. Wang;Y.-Y. Cheng;C.-T. Fan
core  

International consensus on clinical use of presynaptic dopaminergic positron emission tomography imaging in parkinsonism.

Presynaptic dopaminergic positron emission tomography (PET) imaging serves as an essential tool in diagnosing and differentiating patients with suspected parkinsonism, including idiopathic Parkinson's disease (PD) and other neurodegenerative and non ...
Prior, J.O., Dou, X., Cahid Civelek, A., Zhou, R., Li, X., Wang, J., Carrio, I., Kang, K.W., Murakami, K., Tian, M., Watanabe, Y., Zhong, Y., Jin, C., Lu, J., Zuo, C., Zhang, H., Yu, C., Liu, F.   +17 more
core   +1 more source

Immunotargeting of Integrin αβ for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model

Molecular Imaging, 2016
To explore suitable imaging probes for early and specific detection of pancreatic cancer, we demonstrated that α 6 β 4 integrin is a good target and employed single-photon emission computed tomography (SPECT) or near-infrared (NIR) imaging for ...
Winn Aung MBBS, PhD, Atsushi B. Tsuji PhD, Hitomi Sudo PhD, Aya Sugyo M.Ed, Takako Furukawa PhD, Yoshinori Ukai PhD, Yoshikazu Kurosawa PhD, Tsuneo Saga MD, PhD   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Imaging ligands targeting glypican-3 receptor expression in hepatocellular carcinoma

, 2022
Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality. Early detection of HCC is important since potentially curative therapies exist in the initial stages of HCC; no curative therapies exist for late-stage HCC.
Zheng, David X., Zheng, Qi-Huang, Grega, Shaun D.   +2 more
core   +1 more source