Results 101 to 110 of about 5,958,984 (296)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Developing a system for the molecular imaging of freely moving rats

, 2012
Using molecular imaging to obtain time-activity data from the organs of living animals that are free to move, behave and respond to stimuli is a tantalising prospect for preclinical investigations.
Ryder, Will., Meikle, Steven R., Kyme, Andre Z., Fulton, Roger R., R Bashir (9897038), Angelis, Georgios., K Popovic (9895133), Bashir, Rezaul., R Fulton (9890711), W Ryder (9897032), S Meikle (9890720), Zhou, Victor., A Kyme (9890708), Eisenhuth, John., Popovic, Kata., G Angelis (9897035), J Eisenhuth (9893696), Weidong Zhou (9847925)   +17 more
core  

Molecular imaging.

Analytical and Bioanalytical Chemistry, 2007
A. Maggi, M. Salvatore
  +8 more sources

In-vitro interaction studies between the amyloid PET tracer florbetaben and the amyloid-beta targeting antibodies lecanemab and donanemab on AD brain samples reveal no interferences

Alzheimer’s Research & Therapy
Background Amyloid PET imaging enables the in vivo visualization and quantification of amyloid-beta deposits in the brain. In research and clinical settings, it is further used to monitor amyloid-beta burden as well as the biological response to disease ...
Andre Mueller, Aleksandar Jovalekic, Marianne Chapleau, Julius Seidel, Maria Ritter, Eva-Maria Bickel, Nadine Kiessling, Emer MacSweeney, Andrew W. Stephens, Norman Koglin   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Experiences from Clinical Research and Routine Use of Florbetaben Amyloid PET—A Decade of Post-Authorization Insights

Pharmaceuticals
Florbetaben (FBB) is a radiopharmaceutical approved by the FDA and EMA in 2014 for the positron emission tomography (PET) imaging of brain amyloid deposition in patients with cognitive impairment who are being evaluated for Alzheimer’s disease (AD) or ...
Aleksandar Jovalekic, Santiago Bullich, Núria Roé-Vellvé, Guilherme Domingues Kolinger, Lorelei R. Howard, Floriana Elsholz, Mariana Lagos-Quintana, Beatriz Blanco-Rodriguez, Esther Pérez-Martínez, Rossella Gismondi, Audrey Perrotin, Marianne Chapleau, Richard Keegan, Andre Mueller, Andrew W. Stephens, Norman Koglin   +15 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

First clinical experience with a dedicated PET for hanging breast molecular imaging

, 2013
[EN] Aim. Recently, a high-resolution dedicated PET system for hanging breast imaging (MAMMI PET) has been developed to improve primary tumor detection and characterization.
Caballero Ontanaya, Luis, Vogel, W., Vrancken Peeters, Marie-Jeanne, Rutgers, Emiel, Valdés Olmos, Renato, Aukema, T. S., Vroonland, Colinda, González Martínez, Antonio Javier, Koolen, Bas, Benlloch Baviera, Jose María   +9 more
core  

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

[18F]FDG WBC labelled PET/CT for the diagnosis of infectious disease: initial experience in a tertiary centre

EJNMMI Research
Background Labelling WBC with [18F]FDG may be an alternative for accurate infection diagnosis, combining the excellent sensitivity of [18F]FDG with the excellent specificity of WBC-labelled SPECT/CT.
Christel Hermann Kamani, Julien Costes, Maxime Panchaud, Kilian Casagrande, Giorgio Treglia, Mario Jreige, Marie Nicod Lalonde, Niklaus Schaefer, Judith Delage, John O. Prior   +9 more
doaj   +1 more source