Results 141 to 150 of about 5,958,984 (296)
Organic molecules for optical imaging
, 2014 This chapter introduces a series of specially designed organic-based dyes and probes that are useful in bioimaging and in vitro/in vivo chemosensing to reveal the locales and conditions of specific subcellular structures, the activity of selected ...
Lam, MHW +7 more
core +1 more source
Translational PsychiatryThe N-methyl-D-aspartate (NMDA) receptor antagonist ketamine is a robust, rapid-acting antidepressant whose molecular effects have not been fully elucidated. Phosphodiesterase-4 (PDE4), which terminates cyclic adenosine monophosphate (cAMP) activity, may
Paul A. Parcon +14 more
doaj +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
In situ and in vitro cryo-EM reveal structures of mycobacterial encapsulin assembly intermediates
Communications BiologyProkaryotes rely on proteinaceous compartments such as encapsulin to isolate harmful reactions. Encapsulin are widely expressed by bacteria, including the Mycobacteriaceae, which include the human pathogens Mycobacterium tuberculosis and Mycobacterium ...
Casper Berger +6 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Towards Protein Network Analysis using TIS Imaging and Exploratory Data Analysis [PDF]
, 2011 Langenkämper D, Kölling J, Khan M, Rajpoot N, Nattkemper TW. Towards Protein Network Analysis using TIS Imaging and Exploratory Data Analysis. Presented at the Workshop on Computational Systems Biology (WCSB), Zürich, Switzerland.Identification, analysis
Nattkemper, Tim Wilhelm ; https://orcid.org/ +4 more
core
Fast mass spectrometry imaging for immunohistochemistry [PDF]
BIO Web of ConferencesShamraeva Mariya +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source