Results 231 to 240 of about 12,274,852 (362)

Focus on molecular imaging [PDF]

Journal of Magnetic Resonance Imaging, 2002
openaire   +2 more sources

Molecular imaging in gastric cancer: state-of-the-art techniques and emerging opportunities. [PDF]

J Transl Med
Lan K, Liu Y, Li R, Sun Z, Huang W.
europepmc   +1 more source

Imaging mass spectrometry approaches for the detection and localisation of drug compounds and small molecules in tissue [PDF]

A crucial and challenging aspect of the drug development process is the requirement to measure the distribution of a pharmaceutical compound and its metabolites in tissue.
Blatherwick, Eleanor Q.
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Molecular Imaging Advances in Endometriosis: The Promise of Radiopharmaceuticals. [PDF]

Molecules
Napolitano R, Speltri G, Martini P, Porto F, Marvelli L, Niorettini A, Uccelli L, Urso L, Filippi L, Uslu H, Canitez B, Kösem HA, Boschi A.   +12 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Molecular imaging uncovers growth media influence on biofilms' EPS production. [PDF]

Front Chem
Parker GD, Plymale A, Hager J, Hanley L, Yu XY.   +4 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE): Proposed miTNM Classification for the Interpretation of PSMA-Ligand PET/CT

Journal of Nuclear Medicine, 2017
M. Eiber, K. Herrmann, J. Calais, B. Hadaschik, F. Giesel, M. Hartenbach, T. Hope, R. Reiter, T. Maurer, W. Weber, W. Fendler   +10 more
semanticscholar   +1 more source

Spatial Molecular Imaging of the Glycome Using Mass Spectrometry. [PDF]

J Vis Exp
Ribas RA, Paolasso FB, Ryan AM, Sanchez MR, Soto CM, Caffee SI, Larson RC, Allison DB, Gentry MS, Sun RC, Kooi CWV.   +10 more
europepmc   +1 more source