Results 241 to 250 of about 12,274,852 (362)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Advances in neurotensin receptor 1-targeted molecular probes for tumor molecular imaging and therapy. [PDF]

Front Oncol
Liu C, Fu J, Tang S, Hu H, Guo H, Liu T, Wen L, Yang Y, Yang Y, Chen S, Yu L, Zhou H.   +11 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Translational molecular imaging and drug development in multiple sclerosis. [PDF]

Theranostics
Tay D, Ahmed H, Dawoud A, Salam M, Gobbi L, Grether U, Edelmann MR, Wittwer MB, Collin L, Atz K, Keaney J, Giroud M, Rossi A, Gennari AG, Pagano G, Parrot NJ, Barakovic M, Rominger A, Gebhard C, Ametamey SM, Saindane AM, Liang SH, Haider A.   +22 more
europepmc   +1 more source

Molecular imaging in neuropsychiatry [PDF]

International Review of Psychiatry, 2017
Greg M, Pontone, Kelly A, Mills, Gwenn S, Smith   +2 more
openaire   +2 more sources

Correction: Redefining pancreatogenic diabetes mellitus through molecular, imaging, and AI-driven evidence. [PDF]

Front Endocrinol (Lausanne)
Rangraze IR, El-Tanani M, Wali AF, Babiker R, Rabbani SA, Matalka II, Satyam SM, Avagimyan A, Hoffmann K, Ilias I, Ispas S, Viviana M, Paczkowska A, Rizzo M.   +13 more
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Molecular imaging of tucatinib-induced cellular and TME changes in preclinical models of HER2 + breast cancer. [PDF]

Breast Cancer Res Treat
Song PN, Mansur A, Gallegos CA, Ghanate P, Lapi SE, Sorace AG.   +5 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Mapping Alzheimer's disease heterogeneity with molecular imaging biomarkers. [PDF]

Eur J Clin Invest
Harput E, Boccalini C, Mathoux G, Prior JO, Testart N, Jreige M, Garibotto V.   +6 more
europepmc   +1 more source