Results 241 to 250 of about 1,886,243 (328)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Targeted ¹⁹F MRI for molecular imaging of the immune response and its theranostics. [PDF]

Immunother Adv
Bouvain P, Temme S, Flögel U.
europepmc   +1 more source

AGTR1 is overexpressed in neuroendocrine neoplasms, regulates secretion and may serve as a target for molecular imaging and therapy

, 2020
Samantha Exner, Claudia Schuldt, Sachindra Sachindra, Jing Du, Isabelle Heing‐Becker, Kai Licha, Bertram Wiedenmann, Carsten Grötzinger   +7 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

MR molecular imaging for monitoring and predicting tumor responses to immunotherapy. [PDF]

Theranostics
Laney VEA, Zhao W, Hwang IM, Hampson E, Dong J, Hall RC, Weber-Bonk K, Yuan X, Delaney E, Gilmore H, Keri R, Winter J, Wang LL, Lu ZR.   +13 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Approach to the Patient With Primary Aldosteronism: Role of Molecular Imaging.

J Clin Endocrinol Metab
Teo AED, Tran HTN, Khoo CM, Osman I, Tong AK, Foo RSY, Puar TH.   +6 more
europepmc   +1 more source

Future prospects for image-derived input function in molecular imaging quantification with the 7 T MR-BrainPET insert. [PDF]

Front Neurosci
Brambilla CR, Hilgers J, Khalid U, Anasovi N, Kikacheishvili T, Mauler J, Choi CH, Scheins JJ, Shah NJ, Lerche CW.   +9 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Machine Learning-Guided Detection of Malignancy of Lung Nodules With Molecular Imaging-Guided Surgery.

JAMA Netw Open
Azari F, Kennedy GT, Hanna A, Chang A, Chang A, Nadeem B, Din A, Delikatny E, Kucharczuk J, Azari S, Singhal S.   +10 more
europepmc   +1 more source