Results 51 to 60 of about 1,691,605 (247)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Applications of Molecular Imaging [PDF]

, 2010
Today molecular imaging technologies play a central role in clinical oncology. The use of imaging techniques in early cancer detection, treatment response, and new therapy development is steadily growing and has already significantly impacted on clinical management of cancer.
Marcian E. Van Dort, Gary D. Luker, Alnawaz Rehemtulla, Brian D. Ross, Craig J. Galbán, Mahaveer S. Bhojani, Stefanie Galbán   +6 more
openaire   +2 more sources

Endocarditis and molecular imaging [PDF]

Journal of Nuclear Cardiology, 2014
Clinically managing acute endocarditis, an infection of the heart valves with a mortality rate of up to 47%, remains highly challenging and frequently unsuccessful (1, 2). The most common pathogen behind acute endocarditis is Staphylococcus aureus, followed by Streptococcus species (2, 3). Unmet clinical needs in treating acute endocarditis include: (i)
Peter Panizzi, James R. Stone, Matthias Nahrendorf   +2 more
openaire   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Imaging the Breakdown of Molecular-Frame Dynamics through Rotational Uncoupling

, 2017
We demonstrate the breakdown of molecular-frame dynamics induced by the uncoupling of molecular rotation from electronic motion in molecular Rydberg states. We observe this non-Born-Oppenheimer regime in the time domain through photoelectron imaging of a
Bucksbaum, Philip H., Natan, Adi, Zipp, Lucas J.   +2 more
core   +1 more source

Molecular imaging in the eye

British Journal of Ophthalmology, 2009
Molecular imaging plays an increasingly powerful role in elucidating pathophysiological pathways, in advancing drug discovery and in deciphering developmental processes. Multiple modalities, including optical imaging, ultrasound, nuclear imaging, computed tomography and various techniques of MRI are now being used to obtain fundamental new insights at ...
openaire   +3 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

A shallow though extensive H2 2.12 micron imaging survey of Taurus-Auriga-Perseus: I. NGC1333, L1455, L1448 and B1

, 2008
We discuss wide-field near-IR imaging of the NGC1333, L1448, L1455 and B1 star forming regions in Perseus. The observations have been extracted from a much larger narrow-band imaging survey of the Taurus-Auriga-Perseus complex.
A. Adamson, Allen, Arce, Aspin, Bachiller, Bally, Bally, Bate, Bontemps, C. J. Davis, Casali, Chrysostomou, Dame, Davis, Davis, Davis, de Zeeuw, Dobashi, Dye, Eislöffel, Eislöffel, Evans, Evans, Fazio, Gutermuth, Gutermuth, Harvey, Harvey, Hatchell, Hatchell, Hatchell, Heathcote, Hewett, Hirano, Hodapp, Hodapp, Jennings, Jørgensen, Jørgensen, Kirk, Kirk, Knee, Kumar, Lada, Ladd, Lawrence, Lee, Lopez, Lucas, Luhman, Luhman, M. D. Smith, P. Lucas, P. Scholz, Ridge, Rieke, Rodriguez, Sargent, Smith, Smith, Takami, Terquem, Tobin, Velusamy, Walawender, Walawender, Walawender, Ward-Thompson, Whitney, Černis   +69 more
core   +1 more source

Image patterned molecular delivery into live cells using gold particle coated substrates. [PDF]

, 2010
An image-patterned molecular delivery system for mammalian cells is demonstrated by pulsed laser irradiation of gold particles immobilized on a substrate below a cell monolayer.
Callahan, Caitlin, Chiou, Pei-Yu, Kalim, Sheraz, Teitell, Michael A, Wu, Ting-Hsiang   +4 more
core   +1 more source