Results 71 to 80 of about 1,886,243 (328)
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
EJNMMI Physics, 2023 Background Kinetic modeling in positron emission tomography (PET) requires measurement of the tracer plasma activity in the absence of a suitable reference region.
Alan Miranda +3 more
doaj +1 more source
Extensive microscale N isotopic heterogeneity in chondritic organic matter [PDF]
, 2005 Introduction: H and N isotopic anomalies (mainly excesses of D and 15N) in organic matter from primitive meteorites and IDPs suggest preservation of presolar molecular cloud material [1-3].
Alexander, C. M. O'D. +4 more
core
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Chemical Self Assembly of Graphene Sheets [PDF]
, 2009 Chemically derived graphene sheets were found to self-assemble onto patterned gold structures via electrostatic interactions between noncovalent functional groups on GS and gold. This afforded regular arrays of single graphene sheets on large substrates,
Dai, Hongjie +3 more
core +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
EJNMMI Research, 2017 Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four 11C-labeled ligands—(R)-PK11195, PBR28, DPA-713, and ER176—to quantify ...
Masahiro Fujita +10 more
doaj +1 more source
Neuroimaging as a selection tool and endpoint in preclinical and clinical trials [PDF]
, 2016 Standard imaging in acute stroke enables the exclusion of non-stroke structural CNS lesions and cerebral haemorrhage from clinical and pre-clinical ischaemic stroke trials. In this review, the potential benefit of imaging (e.g., angiography and penumbral
Macrae, I. Mhairi, Muir, Keith W.
core +2 more sources
Targeted Molecular Imaging [PDF]
Korean Journal of Radiology, 2003 Molecular imaging aims to visualize the cellular and molecular processes occurring in living tissues, and for the imaging of specific molecules in vivo, the development of reporter probes and dedicated imaging equipment is most important. Reporter genes can be used to monitor the delivery and magnitude of therapeutic gene transfer, and the time ...
openaire +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source