Results 111 to 120 of about 7,519,015 (293)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

MOLECULAR PLANT-MICROBE INTERACTIONS

, 2009
Work on the interaction of aerial plant parts with pathogens has identified the signaling molecules jasmonic acid (JA) and salicylic acid (SA) as important players in induced defense of the plant against invading organisms.
Gutjahr, C., Paszkowski, U.
core   +1 more source

Trace element-linked DNA methylation sites and their association with type 2 diabetes and cardiovascular diseases: EPIC-Potsdam cohort study

Clinical Epigenetics
Background The trace elements (TEs) selenium, zinc, copper, manganese, iodine and iron are essential micronutrients that support essential metabolic functions.
Barbaros Eroglu, Fabian Eichelmann, Olga Kuxhaus, Anna P. Kipp, Tanja Schwerdtle, Hajo Haase, Lutz Schomburg, Matthias B. Schulze   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Plant basal resistance: genetics, biochemistry, and impacts on plant-biotic interactions [PDF]

, 2012
Basal resistance depends largely on a diverse range of defence mechanisms that become active upon attack by pathogens or insects. These mechanisms range from rapid stomatal closure and production of reactive oxygen species, to callose deposition and ...
Ahmad, S., Sub Plant-Microbe Interactions, Plant Microbe Interactions   +2 more
core  

Correlations between molecular numbers and molecular masses in an evanescent field and their applications in probing molecular interactions

, 2005
Complex numbers: The number of molecules detected in the evanescent field during single-molecule fluorescence imaging decreases with increasing molecular weight in free solution (see graphic; FITC = fluorescein isothiocyanate).
Ma, YF, Gai, Hongwei, Bingcheng Lin, Hongwei Gai, Gai, HW, Yinfa Ma, Lin, BC, Lin, Bingcheng, 林炳承, Wang, Qi, Qi Wang, Wang, Q, Ma, Yinfa   +12 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Trace elements and risk of diabetes-related vascular complications: results from the EPIC-Potsdam cohort study

Cardiovascular Diabetology
Background The trace elements selenium, zinc, copper, manganese, iodine, and iron are crucial for various physiological processes, including enzymatic reactions and immune responses.
Barbaros Eroglu, Fabian Eichelmann, Olga Kuxhausf, Anna P. Kipp, Tanja Schwerdtle, Hajo Haase, Lutz Schomburg, Matthias B. Schulze   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source