Results 111 to 120 of about 18,661,987 (346)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A new pea cadmium tolerant mutant in a unique tool for studying molecular plant-microbe interactions under cadmium stress

, 2004
Tsyganov VE, Belimov AA, Safronova VI, et al. A new pea cadmium tolerant mutant in a unique tool for studying molecular plant-microbe interactions under cadmium stress. In: Tikhonovich I, Lugtenberg B, Provorov N, eds.
Borisov, Alexey Y., Dietz, Karl-Josef, Lugtenberg, B., Provorov, N., Safronova, Vera I., Belimov, Andrei A., Tsyganov, Viktor E., Naumkina, T. S., Tikhonovich, Igor, Tikhonovich, I. A.   +9 more
core  

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding

Nature Communications, 2017
An understanding of the dynamics of drug binding and unbinding processes is important for drug discovery. Here, the authors give insights into the binding mechanism of small drug-like molecules to human Hsp90 by combining thermodynamics and kinetics ...
M. Amaral, D. B. Kokh, J. Bomke, A. Wegener, H. P. Buchstaller, H. M. Eggenweiler, P. Matias, C. Sirrenberg, R. C. Wade, M. Frech   +9 more
doaj   +1 more source

Nanoparticle decoration with surfactants: Molecular interactions, assembly, and applications

, 2017
Nanostructures of diverse chemical nature are used as biomarkers, therapeutics, catalysts, and structural reinforcements. The decoration with surfactants has a long history and is essential to introduce specific functions.
Hendrik Heinz, Chandrani Pramanik, Ozge Heinz, Yi-Fu Ding, Ratan K. Mishra, D. Marchon, R. Flatt, I. Estrela-Lopis, J. Llop, S. Moya, R. Ziolo   +10 more
semanticscholar   +1 more source

Molecular interactions at the surface of extracellular vesicles

Seminars in Immunopathology, 2018
Extracellular vesicles such as exosomes, microvesicles, apoptotic bodies, and large oncosomes have been shown to participate in a wide variety of biological processes and are currently under intense investigation in many different fields of biomedicine ...
E. Buzás, Eszter Á. Tóth, Barbara W. Sódar, K. Szabó-Taylor   +3 more
semanticscholar   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Quantifying Protein-Protein Interactions in Molecular Simulations [PDF]

, 2019
We present simple, accurate, and efficient methods to estimate the dissociation constant Kd and the second osmotic virial coefficient B2 from molecular simulations.
Patrick K. Quoika (8163324), Juergen, Koefinger, Gerhard Hummer (6081818), Juergen Koefinger (6068366), Alfredo, Jost Lopez, Alfredo Jost Lopez (8163297), Patrick K., Quoika, Max, Linke, Max Linke (8163318), Gerhard, Hummer   +9 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source