Results 91 to 100 of about 1,965,985 (318)

Noncovalent interactions between hydroxylated polycyclic aromatic hydrocarbon and DNA: Molecular docking and QSAR study [PDF]

, 2011
Polycyclic aromatic hydrocarbons (PAHs) can be hydroxylated by CYP450-oxidases (1A1 and 1B1 mainly) and may cause DNA damage and cancer. However, the mechanism of such interactions has not been fully understood.
Fei Li, Jianmin Zhao, You, Liping, Xuehua Li, Xiaoli Liu, Liu, Xiaoli, Liping You, Wu, Huifeng, Huifeng Wu, Li, Xuehua, Linbao Zhang, Li, Fei, Zhang, Linbao, Zhao, Jianmin   +13 more
core   +1 more source

Dicistrovirus-Host Molecular Interactions

Current Issues in Molecular Biology, 2019
Members of the family Dicistroviridae are small RNA viruses containing a monopartite positive-sense RNA genome. Dicistroviruses mainly infect arthropods, causing diseases that impact agriculture and the economy. In this chapter, we provide an overview of current and past research on dicistroviruses including the viral life cycle, viral translational ...
Reid, Warsaba, Jibin, Sadasivan, Eric, Jan   +2 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Using Surface Plasmon Resonance to Quantitatively Assess Lipid–Protein Interactions [PDF]

, 2016
Surface Plasmon Resonance (SPR) is a quantitative, label-free method for determining molecular interactions in real time. The technology involves fixing a ligand onto a senor chip, measuring a baseline resonance angle, and flowing an analyte in bulk ...
Kathryn Del Vecchio, Stahelin, Robert V., Robert V. Stahelin, Del Vecchio, Kathryn   +3 more
core   +1 more source

Signatures of host specialization and a recent transposable element burst in the dynamic one-speed genome of the fungal barley powdery mildew pathogen

BMC Genomics, 2018
Background Powdery mildews are biotrophic pathogenic fungi infecting a number of economically important plants. The grass powdery mildew, Blumeria graminis, has become a model organism to study host specialization of obligate biotrophic fungal pathogens.
Lamprinos Frantzeskakis, Barbara Kracher, Stefan Kusch, Makoto Yoshikawa-Maekawa, Saskia Bauer, Carsten Pedersen, Pietro D. Spanu, Takaki Maekawa, Paul Schulze-Lefert, Ralph Panstruga   +9 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Membrane interactions of S100A12 (Calgranulin C) [PDF]

, 2013
S100A12 (Calgranulin C) is a small acidic calcium-binding peripheral membrane protein with two EF-hand structural motifs. It is expressed in macrophages and lymphocytes and highly up-regulated in several human inflammatory diseases.
Costa-Filho, A.J., Wallace, Bonnie A., Araujo, A.P.U., Hofmann, A., Garcia, A.F., Lopes, J.L.S.   +5 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Specific antigen/antibody interactions measured by force microscopy [PDF]

, 1996
Dammer U, Hegner M, Anselmetti D, et al. Specific antigen/antibody interactions measured by force microscopy. Biophysical journal. 1996;70(5):2437-2441.Molecular recognition between biotinylated bovine serum albumin and polyclonal, biotin-directed IgG ...
Dreier, M., Dammer, Ulrich, Hegner, M., H.J. Güntherodt, Güntherodt, H.J., Wagner, Peter, U. Dammer, M. Dreier, Wagner, P., D. Anselmetti, Hegner, Martin, Huber, Walter, Güntherodt, Hans-Joachim, Huber, W., W. Huber, Anselmetti, D., Dreier, Markus, Dammer, U., P. Wagner, Anselmetti, Dario ; https://orcid.org/, M. Hegner   +20 more
core   +2 more sources

Antibacterial Activity and Proposed Mode of Action of Extracts from Selected Zimbabwean Medicinal Plants against Acinetobacter baumannii

Advances in Pharmacological and Pharmaceutical Sciences
Acinetobacter baumannii was identified by the WHO as a priority pathogen in which the research and development of new antibiotics is urgently needed. Plant phytochemicals have potential as sources of new antimicrobials.
Auxillia Machingauta, Stanley Mukanganyama   +1 more
doaj   +1 more source