Results 71 to 80 of about 18,661,987 (346)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Molecular Basis for Polyketide Ketoreductase-Substrate Interactions. [PDF]

, 2020
Polyketides are a large class of structurally and functionally diverse natural products with important bioactivities. Many polyketides are synthesized by reducing type II polyketide synthases (PKSs), containing transiently interacting standalone enzymes.
Tsai, Shiou-Chuan, Fanglue Ni, Qiu, Tianyin, Ni, Fanglue, Jacob Wolff, Luo, Ray, Shiou-Chuan Tsai, Wolff, Jacob T, Ray Luo, Zhao, Shiji, Shiji Zhao, Tianyin Qiu   +11 more
core   +1 more source

Limited impact of hepatitis A virus 3C protease-mediated cleavage on the functions of NEMO in human hepatocytes

Journal of Virology
NF-κB essential modulator (NEMO) is critically involved in the induction of interferons (IFNs) and pro-inflammatory cytokines. Hepatitis A virus (HAV) 3C protease was recently identified to cleave NEMO in non-hepatic cells.
Hao-En Huang, Ombretta Colasanti, Teng-Feng Li, Volker Lohmann   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Correlations between molecular numbers and molecular masses in an evanescent field and their applications in probing molecular interactions

, 2005
Complex numbers: The number of molecules detected in the evanescent field during single-molecule fluorescence imaging decreases with increasing molecular weight in free solution (see graphic; FITC = fluorescein isothiocyanate).
Ma, YF, Gai, Hongwei, Bingcheng Lin, Hongwei Gai, Gai, HW, Yinfa Ma, Lin, BC, Lin, Bingcheng, 林炳承, Wang, Qi, Qi Wang, Wang, Q, Ma, Yinfa   +12 more
core   +1 more source

Molecular Interactions Using New Technology: A Virtual Reality Gaming Platform to Visualize and Manipulate Molecules [PDF]

, 2019
The representation of complex biomolecular structures and interactions is a difficult challenge across life sciences. Researchers and students use unintuitive 2D representations to gain an intuitive understanding of 3D space and molecular interactions ...
Gaurav Chopra (4761354), Jordon, McGraw, Jonathan A Fine (7027766), Christopher Sculley (7412948), Gaurav, Chopra, Jordon McGraw (7412941), Wei Zhang (7412946), Jonathan A, Fine, Christopher, Sculley, Wei, Zhang   +9 more
core   +1 more source

Molecular Interactions Between Reactive Oxygen Species and Autophagy in Kidney Disease

International Journal of Molecular Sciences, 2019
Reactive oxygen species (ROS) are highly reactive signaling molecules that maintain redox homeostasis in mammalian cells. Dysregulation of redox homeostasis under pathological conditions results in excessive generation of ROS, culminating in oxidative ...
G. Kaushal, K. Chandrashekar, L. Juncos
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Virus-induced Gene Silencing (VIGS) in Barley Seedling Leaves

Bio-Protocol, 2015
Virus induced gene silencing (VIGS) is one of the most potent reverse genetics technologies for gene functional characterisation. This method exploits a dsRNA-mediated antiviral defence mechanism in plants.
Lokanadha Gunupuru, Shahin Ali, Fiona Doohan, Steven Scofield   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source